Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 445273..446072 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag OC617_RS16295 Protein ID WP_000118351.1
Coordinates 445539..446072 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag OC617_RS16290 Protein ID WP_000179600.1
Coordinates 445273..445542 (+) Length 90 a.a.

Genomic Context

OC617_RS16230OC617_RS16235OC617_RS16240OC617_RS16245OC617_RS16250OC617_RS16255OC617_RS16270OC617_RS16275OC617_RS16280OC617_RS16285OC617_RS16290OC617_RS16295OC617_RS16300OC617_RS16305OC617_RS16310OC617_RS16315OC617_RS16320OC617_RS16325OC617_RS16330OC617_RS16335OC617_RS16340OC617_RS16260OC617_RS16265
Location: 440647..440898 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 440888..441175 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 441303..441758 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 441815..441937 (123 bp)
Type: Others
Protein ID: Protein_471
Location: 442108..442232 (125 bp)
Type: Others
Protein ID: Protein_472
Location: 442349..442417 (69 bp)
Type: Others
Protein ID: Protein_473
Location: 443352..443414 (63 bp)
Type: Others
Protein ID: Protein_476
Location: 443431..444099 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 444251..444538 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 444679..445050 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 445273..445542 (270 bp)
Type: Antitoxin
Protein ID: WP_000179600.1
Location: 445539..446072 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 446082..446192 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 446274..446531 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 446519..446821 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 447055..447972 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 448129..448518 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 448654..448863 (210 bp)
Type: Others
Protein ID: Protein_487
Location: 448982..449419 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 449480..449701 (222 bp)
Type: Others
Protein ID: Protein_489
Location: 449876..450748 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 442434..442931 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 442928..443200 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS16230 (CNRVC190243H_03181)440647..440898+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
OC617_RS16235 (CNRVC190243H_03182)440888..441175+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
OC617_RS16240 (CNRVC190243H_03183)441303..441758+456WP_001245327.1GNAT family N-acetyltransferase-
OC617_RS16245441815..441937+123Protein_471acetyltransferase-
OC617_RS16250442108..442232+125Protein_472DUF645 family protein-
OC617_RS16255442349..442417+69Protein_473acetyltransferase-
OC617_RS16260 (CNRVC190243H_03184)442434..442931-498WP_000982260.1GNAT family N-acetyltransferase-
OC617_RS16265 (CNRVC190243H_03185)442928..443200-273WP_000246253.1DUF1778 domain-containing protein-
OC617_RS16270443352..443414+63Protein_476acetyltransferase-
OC617_RS16275 (CNRVC190243H_03186)443431..444099+669WP_000043871.1hypothetical protein-
OC617_RS16280 (CNRVC190243H_03187)444251..444538+288WP_000426470.1hypothetical protein-
OC617_RS16285 (CNRVC190243H_03188)444679..445050+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
OC617_RS16290 (CNRVC190243H_03189)445273..445542+270WP_000179600.1DUF1778 domain-containing proteinAntitoxin
OC617_RS16295 (CNRVC190243H_03190)445539..446072+534WP_000118351.1GNAT family N-acetyltransferaseToxin
OC617_RS16300446082..446192+111WP_086010065.1DUF3265 domain-containing protein-
OC617_RS16305 (CNRVC190243H_03191)446274..446531+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
OC617_RS16310 (CNRVC190243H_03192)446519..446821+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
OC617_RS16315 (CNRVC190243H_03193)447055..447972+918WP_000186333.1alpha/beta hydrolase-
OC617_RS16320 (CNRVC190243H_03194)448129..448518+390WP_001081302.1hypothetical protein-
OC617_RS16325 (CNRVC190243H_03195)448654..448863+210Protein_487GNAT family N-acetyltransferase-
OC617_RS16330 (CNRVC190243H_03196)448982..449419+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
OC617_RS16335 (CNRVC190243H_03197)449480..449701+222Protein_489GNAT family N-acetyltransferase-
OC617_RS16340 (CNRVC190243H_03198)449876..450748+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049
flankIS/Tn--448982..449419437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T295399 WP_000118351.1 NZ_OW443148:445539-446072 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT295399 WP_000179600.1 NZ_OW443148:445273-445542 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K9UER4

References