56916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 363424..363952 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag AN947_RS01960 Protein ID WP_000221352.1
Coordinates 363424..363714 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag AN947_RS01965 Protein ID WP_000213183.1
Coordinates 363704..363952 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS20755 358694..358804 + 111 WP_134814058.1 DUF3265 domain-containing protein -
AN947_RS01920 358981..359106 + 126 WP_001944767.1 DUF645 family protein -
AN947_RS20760 359122..359160 + 39 WP_106019119.1 hypothetical protein -
AN947_RS01930 359373..360377 + 1005 WP_000964925.1 LD-carboxypeptidase -
AN947_RS01935 360530..360976 + 447 WP_000128977.1 hypothetical protein -
AN947_RS01940 361096..362025 + 930 WP_000335802.1 hypothetical protein -
AN947_RS01945 362022..362132 + 111 WP_071917832.1 DUF3265 domain-containing protein -
AN947_RS01950 362160..362636 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
AN947_RS01955 362773..363288 + 516 WP_001201532.1 lipocalin family protein -
AN947_RS01960 363424..363714 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN947_RS01965 363704..363952 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AN947_RS01975 364523..365176 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
AN947_RS01980 365448..365873 + 426 WP_000415748.1 hypothetical protein -
AN947_RS01985 366081..366476 + 396 WP_000649527.1 DUF3465 domain-containing protein -
AN947_RS01990 366627..367157 + 531 WP_000415563.1 hypothetical protein -
AN947_RS01995 367295..367795 + 501 WP_000789723.1 hypothetical protein -
AN947_RS02005 367951..368349 + 399 WP_001882293.1 hypothetical protein -
AN947_RS02010 368449..368913 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T56916 WP_000221352.1 NZ_CP012666:c363714-363424 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T56916 NZ_CP012666:c363714-363424 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT56916 WP_000213183.1 NZ_CP012666:c363952-363704 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT56916 NZ_CP012666:c363952-363704 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References