180870

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 416329..416867 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag IT766_RS15675 Protein ID WP_000802136.1
Coordinates 416329..416628 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag IT766_RS15680 Protein ID WP_001107719.1
Coordinates 416625..416867 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS15635 412264..412446 + 183 WP_000923182.1 DUF645 family protein -
IT766_RS15640 412646..413119 + 474 WP_001161076.1 GrpB family protein -
IT766_RS15645 413134..413226 + 93 WP_014378730.1 DUF3265 domain-containing protein -
IT766_RS15650 413268..413894 + 627 WP_000365424.1 LysE family translocator -
IT766_RS15655 414017..414715 + 699 WP_001890502.1 hypothetical protein -
IT766_RS15660 414725..414835 + 111 WP_079857360.1 DUF3265 domain-containing protein -
IT766_RS15665 415413..415592 + 180 WP_001883058.1 DUF645 family protein -
IT766_RS15670 415806..416201 + 396 WP_000870857.1 DUF3465 domain-containing protein -
IT766_RS15675 416329..416628 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT766_RS15680 416625..416867 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IT766_RS15685 417096..417674 + 579 WP_000110120.1 hypothetical protein -
IT766_RS15690 417696..417788 + 93 WP_014164112.1 DUF3265 domain-containing protein -
IT766_RS15695 418212..418895 + 684 WP_000877436.1 hypothetical protein -
IT766_RS15700 419109..419375 + 267 WP_000937852.1 hypothetical protein -
IT766_RS15705 419530..420129 + 600 WP_000429495.1 hypothetical protein -
IT766_RS15710 420410..421345 + 936 WP_000051985.1 restriction endonuclease -
IT766_RS15715 421311..421451 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T180870 WP_000802136.1 NZ_CP064351:c416628-416329 [Vibrio cholerae C6706]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T180870 NZ_CP085767:2042256-2042648 [Enterobacter hormaechei]
ATGCTGCATATGCTGGACACTAACATCGTAAGCCATCTGGTGAGGCAGCATCCTGAAGTTGTAAACCGATATTCGCAAAT
TACGCCTGAAAAGATGTGTATTTCAAGCGTAACGGAAGCGGAATTGCTTTACGGCGTAGCCAAAAAGCAAAACAACAAGC
TGCACGAAACCATAATGGAATTTCTTAAAACCATCACTGTCTGCGCCTGGGATAGCGAAGCCGCAGCCATCTACGGTGAA
CTGCGTGCGGCAATGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAGTTGATTGCCGCACATGCTATCAGCCGGGG
CACGACGATTGTCACGAACGATCATGCGTTCGGGATGGTACAGGATCTTACGGTTGAGGACTGGACTCAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT180870 WP_001107719.1 NZ_CP064351:c416867-416625 [Vibrio cholerae C6706]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT180870 NZ_CP085767:2041992-2042252 [Enterobacter hormaechei]
ATGGAACGCACAGCGAAACTATTCAAAAAAGGACGAAACCAGGCCGTGGTCTTGCCTGCGGAATTTGCGTTTGAAACGGA
GAGTGTTTATATCCGCCGGGATGACGAGGGGAATGTGGTTTTGACGGCAAGGTCCGAGAAAGCACGGCACAGGGATAACT
TTTTGCGCATGTTAAAAGAAACGCATGTGCCTGATACCTTTCTAAGTAAAGAGGAGCGCAATCAGAGCTATACGACAAGA
AACCCTCTTGAAGGGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References