Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 416329..416867 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag IT766_RS15675 Protein ID WP_000802136.1
Coordinates 416329..416628 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag IT766_RS15680 Protein ID WP_001107719.1
Coordinates 416625..416867 (-) Length 81 a.a.

Genomic Context

IT766_RS15635IT766_RS15640IT766_RS15645IT766_RS15650IT766_RS15655IT766_RS15660IT766_RS15665IT766_RS15670IT766_RS15685IT766_RS15690IT766_RS15695IT766_RS15700IT766_RS15705IT766_RS15710IT766_RS15715IT766_RS15675IT766_RS15680
Location: 412264..412446 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 412646..413119 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 413134..413226 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 413268..413894 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 414017..414715 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 414725..414835 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 415413..415592 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 415806..416201 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 417096..417674 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 417696..417788 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 418212..418895 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 419109..419375 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 419530..420129 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 420410..421345 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 421311..421451 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 416329..416628 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 416625..416867 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT766_RS15635412264..412446+183WP_000923182.1DUF645 family protein-
IT766_RS15640412646..413119+474WP_001161076.1GrpB family protein-
IT766_RS15645413134..413226+93WP_014378730.1DUF3265 domain-containing protein-
IT766_RS15650413268..413894+627WP_000365424.1LysE family translocator-
IT766_RS15655414017..414715+699WP_001890502.1hypothetical protein-
IT766_RS15660414725..414835+111WP_079857360.1DUF3265 domain-containing protein-
IT766_RS15665415413..415592+180WP_001883058.1DUF645 family protein-
IT766_RS15670415806..416201+396WP_000870857.1DUF3465 domain-containing protein-
IT766_RS15675416329..416628-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IT766_RS15680416625..416867-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
IT766_RS15685417096..417674+579WP_000110120.1hypothetical protein-
IT766_RS15690417696..417788+93WP_014164112.1DUF3265 domain-containing protein-
IT766_RS15695418212..418895+684WP_000877436.1hypothetical protein-
IT766_RS15700419109..419375+267WP_000937852.1hypothetical protein-
IT766_RS15705419530..420129+600WP_000429495.1hypothetical protein-
IT766_RS15710420410..421345+936WP_000051985.1restriction endonuclease-
IT766_RS15715421311..421451+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-373204..502464129260
insideIntegron--378284..502088123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T180870 WP_000802136.1 NZ_CP064351:c416628-416329 [Vibrio cholerae C6706]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T180870 NZ_CP085767:2042256-2042648 [Enterobacter hormaechei]
ATGCTGCATATGCTGGACACTAACATCGTAAGCCATCTGGTGAGGCAGCATCCTGAAGTTGTAAACCGATATTCGCAAAT
TACGCCTGAAAAGATGTGTATTTCAAGCGTAACGGAAGCGGAATTGCTTTACGGCGTAGCCAAAAAGCAAAACAACAAGC
TGCACGAAACCATAATGGAATTTCTTAAAACCATCACTGTCTGCGCCTGGGATAGCGAAGCCGCAGCCATCTACGGTGAA
CTGCGTGCGGCAATGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAGTTGATTGCCGCACATGCTATCAGCCGGGG
CACGACGATTGTCACGAACGATCATGCGTTCGGGATGGTACAGGATCTTACGGTTGAGGACTGGACTCAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT180870 WP_001107719.1 NZ_CP064351:c416867-416625 [Vibrio cholerae C6706]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT180870 NZ_CP085767:2041992-2042252 [Enterobacter hormaechei]
ATGGAACGCACAGCGAAACTATTCAAAAAAGGACGAAACCAGGCCGTGGTCTTGCCTGCGGAATTTGCGTTTGAAACGGA
GAGTGTTTATATCCGCCGGGATGACGAGGGGAATGTGGTTTTGACGGCAAGGTCCGAGAAAGCACGGCACAGGGATAACT
TTTTGCGCATGTTAAAAGAAACGCATGTGCCTGATACCTTTCTAAGTAAAGAGGAGCGCAATCAGAGCTATACGACAAGA
AACCCTCTTGAAGGGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References