Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 907114..907661 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag DG247_RS18415 Protein ID WP_000229317.1
Coordinates 907114..907416 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag DG247_RS18420 Protein ID WP_000861987.1
Coordinates 907404..907661 (-) Length 86 a.a.

Genomic Context

DG247_RS18455DG247_RS18460DG247_RS18375DG247_RS18380DG247_RS18385DG247_RS18390DG247_RS18395DG247_RS18400DG247_RS18405DG247_RS18410DG247_RS18415DG247_RS18420DG247_RS18430DG247_RS18435DG247_RS18440DG247_RS18445DG247_RS18450DG247_RS18470DG247_RS18475
Location: 910735..911007 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 911004..911501 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 902277..902381 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 902438..903037 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 903187..904059 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 904234..904452 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 904516..904953 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 905072..905281 (210 bp)
Type: Others
Protein ID: Protein_767
Location: 905417..905806 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 905963..906880 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 907114..907416 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 907404..907661 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 907863..908396 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 908393..908818 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 908885..909256 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 909397..909684 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 909836..910504 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 911703..911855 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 912177..912632 (456 bp)
Type: Others
Protein ID: WP_001245327.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS18375902277..902381-105WP_099607150.1acetyltransferase-
DG247_RS18380902438..903037-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
DG247_RS18385903187..904059-873WP_000254716.1DUF3800 domain-containing protein-
DG247_RS18390904234..904452-219WP_071908318.1GNAT family N-acetyltransferase-
DG247_RS18395904516..904953-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
DG247_RS18400905072..905281-210Protein_767GNAT family N-acetyltransferase-
DG247_RS18405905417..905806-390WP_001081302.1hypothetical protein-
DG247_RS18410905963..906880-918WP_000186333.1alpha/beta hydrolase-
DG247_RS18415907114..907416-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG247_RS18420907404..907661-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG247_RS18430907863..908396-534WP_000118351.1GNAT family N-acetyltransferase-
DG247_RS18435908393..908818-426WP_001882332.1DUF1778 domain-containing protein-
DG247_RS18440908885..909256-372WP_001164080.1nucleotide pyrophosphohydrolase-
DG247_RS18445909397..909684-288WP_000426470.1hypothetical protein-
DG247_RS18450909836..910504-669WP_000043871.1hypothetical protein-
DG247_RS18455910735..911007+273WP_000246253.1DUF1778 domain-containing protein-
DG247_RS18460911004..911501+498WP_000982260.1GNAT family N-acetyltransferase-
DG247_RS18470911703..911855-153WP_001884520.1DUF645 family protein-
DG247_RS18475912177..912632-456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808
flankIS/Tn--904516..904953437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T294351 WP_000229317.1 NZ_LT992487:c907416-907114 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT294351 WP_000861987.1 NZ_LT992487:c907661-907404 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References