Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | dhiT-phd/- |
Location | 217114..217518 | Replicon | chromosome |
Accession | NZ_CP013316 | ||
Organism | Vibrio cholerae strain M2140 |
Toxin (Protein)
Gene name | dhiT | Uniprot ID | A0A086SLD6 |
Locus tag | ASZ83_RS15595 | Protein ID | WP_001114075.1 |
Coordinates | 217249..217518 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | - |
Locus tag | ASZ83_RS20230 | Protein ID | WP_099607150.1 |
Coordinates | 217114..217218 (+) | Length | 35 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ83_RS15550 | 212615..213532 | + | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
ASZ83_RS15560 | 213689..214078 | + | 390 | WP_001081302.1 | hypothetical protein | - |
ASZ83_RS15565 | 214214..214423 | + | 210 | Protein_296 | GNAT family N-acetyltransferase | - |
ASZ83_RS15570 | 214542..214979 | + | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
ASZ83_RS15575 | 215043..215261 | + | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
ASZ83_RS15585 | 215436..216308 | + | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
ASZ83_RS15590 | 216458..217057 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
ASZ83_RS20230 | 217114..217218 | + | 105 | WP_099607150.1 | acetyltransferase | Antitoxin |
ASZ83_RS15595 | 217249..217518 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
ASZ83_RS15600 | 217512..218033 | + | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
ASZ83_RS20235 | 218332..218457 | + | 126 | WP_001905700.1 | DUF645 family protein | - |
ASZ83_RS15615 | 218708..219103 | + | 396 | WP_001000867.1 | hypothetical protein | - |
ASZ83_RS15620 | 219242..219520 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
ASZ83_RS15625 | 219517..219801 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
ASZ83_RS15630 | 219995..220510 | + | 516 | WP_000343779.1 | GNAT family N-acetyltransferase | - |
ASZ83_RS15635 | 220694..221107 | + | 414 | WP_000049420.1 | VOC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 87981..224211 | 136230 | |
inside | Integron | - | - | 93061..221594 | 128533 | ||
flank | IS/Tn | - | - | 214542..214979 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T58387 WP_001114075.1 NZ_CP013316:217249-217518 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T58387 NZ_CP013316:217249-217518 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
Antitoxin
Download Length: 35 a.a. Molecular weight: 3991.79 Da Isoelectric Point: 9.2853
>AT58387 WP_099607150.1 NZ_CP013316:217114-217218 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
Download Length: 105 bp
>AT58387 NZ_CP013316:217114-217218 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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