48156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 394129..394657 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag IR04_RS01990 Protein ID WP_000221354.1
Coordinates 394370..394657 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag IR04_RS01985 Protein ID WP_001250179.1
Coordinates 394129..394380 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS01945 389397..389711 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
IR04_RS01950 389848..390282 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
IR04_RS20250 390450..390605 + 156 WP_000751734.1 hypothetical protein -
IR04_RS01960 390730..391710 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
IR04_RS01965 391778..392050 + 273 Protein_404 CatB-related O-acetyltransferase -
IR04_RS01970 392221..392913 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
IR04_RS01975 392913..393314 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
IR04_RS20025 393284..393427 + 144 WP_071908341.1 DUF3265 domain-containing protein -
IR04_RS01980 393502..393915 + 414 WP_000049417.1 VOC family protein -
IR04_RS01985 394129..394380 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IR04_RS01990 394370..394657 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR04_RS01995 394785..395240 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
IR04_RS02000 395562..395714 + 153 WP_001884520.1 DUF645 family protein -
IR04_RS02005 395916..396413 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
IR04_RS02010 396410..396682 - 273 WP_000246253.1 DUF1778 domain-containing protein -
IR04_RS02015 396913..397581 + 669 WP_000043871.1 hypothetical protein -
IR04_RS02020 397733..398020 + 288 WP_000426470.1 hypothetical protein -
IR04_RS02025 398161..398532 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
IR04_RS02030 398599..399024 + 426 WP_001882332.1 DUF1778 domain-containing protein -
IR04_RS02035 399021..399554 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736
flank IS/Tn - - 390730..391710 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T48156 WP_000221354.1 NZ_CP009041:394370-394657 [Vibrio cholerae O1 biovar El Tor]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T48156 NZ_CP009041:394370-394657 [Vibrio cholerae O1 biovar El Tor]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT48156 WP_001250179.1 NZ_CP009041:394129-394380 [Vibrio cholerae O1 biovar El Tor]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT48156 NZ_CP009041:394129-394380 [Vibrio cholerae O1 biovar El Tor]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References