Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 394129..394657 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag IR04_RS01990 Protein ID WP_000221354.1
Coordinates 394370..394657 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag IR04_RS01985 Protein ID WP_001250179.1
Coordinates 394129..394380 (+) Length 84 a.a.

Genomic Context

IR04_RS01945IR04_RS01950IR04_RS20250IR04_RS01965IR04_RS01970IR04_RS01975IR04_RS20025IR04_RS01980IR04_RS01985IR04_RS01990IR04_RS01995IR04_RS02000IR04_RS02015IR04_RS02020IR04_RS02025IR04_RS02030IR04_RS02035IR04_RS01960IR04_RS02005IR04_RS02010
Location: 389397..389711 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 389848..390282 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 390450..390605 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 391778..392050 (273 bp)
Type: Others
Protein ID: Protein_404
Location: 392221..392913 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 392913..393314 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 393284..393427 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 393502..393915 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 394129..394380 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 394370..394657 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 394785..395240 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 395562..395714 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 396913..397581 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 397733..398020 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 398161..398532 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 398599..399024 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 399021..399554 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 390730..391710 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 395916..396413 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 396410..396682 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS01945389397..389711+315WP_000071008.1DNA-binding transcriptional regulator-
IR04_RS01950389848..390282+435WP_000256036.1GNAT family N-acetyltransferase-
IR04_RS20250390450..390605+156WP_000751734.1hypothetical protein-
IR04_RS01960390730..391710-981WP_000019370.1IS5-like element ISVch5 family transposase-
IR04_RS01965391778..392050+273Protein_404CatB-related O-acetyltransferase-
IR04_RS01970392221..392913+693WP_001047169.1GNAT family N-acetyltransferase-
IR04_RS01975392913..393314+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
IR04_RS20025393284..393427+144WP_071908341.1DUF3265 domain-containing protein-
IR04_RS01980393502..393915+414WP_000049417.1VOC family protein-
IR04_RS01985394129..394380+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
IR04_RS01990394370..394657+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IR04_RS01995394785..395240+456WP_001245327.1GNAT family N-acetyltransferase-
IR04_RS02000395562..395714+153WP_001884520.1DUF645 family protein-
IR04_RS02005395916..396413-498WP_000982260.1GNAT family N-acetyltransferase-
IR04_RS02010396410..396682-273WP_000246253.1DUF1778 domain-containing protein-
IR04_RS02015396913..397581+669WP_000043871.1hypothetical protein-
IR04_RS02020397733..398020+288WP_000426470.1hypothetical protein-
IR04_RS02025398161..398532+372WP_001164080.1nucleotide pyrophosphohydrolase-
IR04_RS02030398599..399024+426WP_001882332.1DUF1778 domain-containing protein-
IR04_RS02035399021..399554+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736
flankIS/Tn--390730..391710980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T48156 WP_000221354.1 NZ_CP009041:394370-394657 [Vibrio cholerae O1 biovar El Tor]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T48156 NZ_CP009041:394370-394657 [Vibrio cholerae O1 biovar El Tor]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT48156 WP_001250179.1 NZ_CP009041:394129-394380 [Vibrio cholerae O1 biovar El Tor]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT48156 NZ_CP009041:394129-394380 [Vibrio cholerae O1 biovar El Tor]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References