Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 231420..231958 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag DG169_RS15615 Protein ID WP_000802136.1
Coordinates 231420..231719 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag DG169_RS15620 Protein ID WP_001107719.1
Coordinates 231716..231958 (-) Length 81 a.a.

Genomic Context

DG169_RS19825DG169_RS15565DG169_RS15570DG169_RS15575DG169_RS15580DG169_RS15585DG169_RS15590DG169_RS15605DG169_RS15610DG169_RS15630DG169_RS15635DG169_RS15645DG169_RS15655DG169_RS15665DG169_RS15670DG169_RS15675DG169_RS15615DG169_RS15620
Location: 227166..227294 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 227355..227537 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 227737..228210 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 228225..228317 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 228359..228985 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 229108..229806 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 229816..229926 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 230504..230683 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 230897..231292 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 232187..232765 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 232787..232879 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 233303..233986 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 234200..234466 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 234621..235220 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 235501..236436 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 236402..236542 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 231420..231719 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 231716..231958 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS19825227166..227294+129WP_071908338.1general secretion pathway protein GspI-
DG169_RS15565227355..227537+183WP_000923182.1DUF645 family protein-
DG169_RS15570227737..228210+474WP_001161076.1GrpB family protein-
DG169_RS15575228225..228317+93WP_014378730.1DUF3265 domain-containing protein-
DG169_RS15580228359..228985+627WP_000365424.1LysE family translocator-
DG169_RS15585229108..229806+699WP_001890502.1hypothetical protein-
DG169_RS15590229816..229926+111WP_079857360.1DUF3265 domain-containing protein-
DG169_RS15605230504..230683+180WP_001883058.1DUF645 family protein-
DG169_RS15610230897..231292+396WP_000870857.1DUF3465 domain-containing protein-
DG169_RS15615231420..231719-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG169_RS15620231716..231958-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
DG169_RS15630232187..232765+579WP_000110120.1hypothetical protein-
DG169_RS15635232787..232879+93WP_014164112.1DUF3265 domain-containing protein-
DG169_RS15645233303..233986+684WP_000877436.1hypothetical protein-
DG169_RS15655234200..234466+267WP_000937852.1hypothetical protein-
DG169_RS15665234621..235220+600WP_000429495.1hypothetical protein-
DG169_RS15670235501..236436+936WP_000051985.1restriction endonuclease-
DG169_RS15675236402..236542+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T294410 WP_000802136.1 NZ_LT992493:c231719-231420 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT294410 WP_001107719.1 NZ_LT992493:c231958-231716 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References