294410

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 231420..231958 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag DG169_RS15615 Protein ID WP_000802136.1
Coordinates 231420..231719 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag DG169_RS15620 Protein ID WP_001107719.1
Coordinates 231716..231958 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG169_RS19825 227166..227294 + 129 WP_071908338.1 general secretion pathway protein GspI -
DG169_RS15565 227355..227537 + 183 WP_000923182.1 DUF645 family protein -
DG169_RS15570 227737..228210 + 474 WP_001161076.1 GrpB family protein -
DG169_RS15575 228225..228317 + 93 WP_014378730.1 DUF3265 domain-containing protein -
DG169_RS15580 228359..228985 + 627 WP_000365424.1 LysE family translocator -
DG169_RS15585 229108..229806 + 699 WP_001890502.1 hypothetical protein -
DG169_RS15590 229816..229926 + 111 WP_079857360.1 DUF3265 domain-containing protein -
DG169_RS15605 230504..230683 + 180 WP_001883058.1 DUF645 family protein -
DG169_RS15610 230897..231292 + 396 WP_000870857.1 DUF3465 domain-containing protein -
DG169_RS15615 231420..231719 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG169_RS15620 231716..231958 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DG169_RS15630 232187..232765 + 579 WP_000110120.1 hypothetical protein -
DG169_RS15635 232787..232879 + 93 WP_014164112.1 DUF3265 domain-containing protein -
DG169_RS15645 233303..233986 + 684 WP_000877436.1 hypothetical protein -
DG169_RS15655 234200..234466 + 267 WP_000937852.1 hypothetical protein -
DG169_RS15665 234621..235220 + 600 WP_000429495.1 hypothetical protein -
DG169_RS15670 235501..236436 + 936 WP_000051985.1 restriction endonuclease -
DG169_RS15675 236402..236542 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 197768..293032 95264
inside Integron catB9 - 202848..292656 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T294410 WP_000802136.1 NZ_LT992493:c231719-231420 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT294410 WP_001107719.1 NZ_LT992493:c231958-231716 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References