198982

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343652..344211 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag J9265_RS15365 Protein ID WP_000578476.1
Coordinates 343652..343930 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag J9265_RS15370 Protein ID WP_000381183.1
Coordinates 343927..344211 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS19045 338800..338922 + 123 WP_001937972.1 DUF3709 domain-containing protein -
J9265_RS15325 (J9265_15325) 339190..339696 + 507 WP_000393074.1 hypothetical protein -
J9265_RS15330 (J9265_15330) 339853..340239 + 387 WP_000703163.1 VOC family protein -
J9265_RS15335 (J9265_15335) 340434..340685 + 252 WP_001890111.1 TIGR03643 family protein -
J9265_RS15340 (J9265_15340) 340658..340807 + 150 WP_071908333.1 DUF3265 domain-containing protein -
J9265_RS15345 (J9265_15345) 340954..341379 + 426 WP_000415750.1 hypothetical protein -
J9265_RS15350 (J9265_15350) 341585..342208 + 624 WP_000247070.1 DUF1349 domain-containing protein -
J9265_RS15355 (J9265_15355) 342421..342900 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
J9265_RS19050 342897..343013 + 117 WP_086010882.1 DUF3265 domain-containing protein -
J9265_RS15360 (J9265_15360) 343088..343501 + 414 WP_000049420.1 VOC family protein -
J9265_RS15365 (J9265_15365) 343652..343930 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
J9265_RS15370 (J9265_15370) 343927..344211 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J9265_RS15375 (J9265_15375) 344460..344921 + 462 WP_001911578.1 lipocalin family protein -
J9265_RS15380 (J9265_15380) 344986..345582 + 597 WP_000255434.1 hypothetical protein -
J9265_RS19055 345776..345913 + 138 WP_001890145.1 hypothetical protein -
J9265_RS15385 (J9265_15385) 345974..346156 + 183 WP_000923182.1 DUF645 family protein -
J9265_RS15390 (J9265_15390) 346356..346829 + 474 WP_001161076.1 GrpB family protein -
J9265_RS15395 (J9265_15395) 346844..346936 + 93 WP_014378730.1 DUF3265 domain-containing protein -
J9265_RS15400 (J9265_15400) 346978..347604 + 627 WP_000365424.1 LysE family translocator -
J9265_RS15405 (J9265_15405) 347727..348425 + 699 WP_001890502.1 hypothetical protein -
J9265_RS15410 (J9265_15410) 348456..348545 + 90 WP_072606010.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T198982 WP_000578476.1 NZ_CP072848:c343930-343652 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T198982 NZ_CP097079:c4675096-4674812 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT198982 WP_000381183.1 NZ_CP072848:c344211-343927 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT198982 NZ_CP097079:c4675328-4675086 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References