Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 498313..498811 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag ASZ87_RS16840 Protein ID WP_000589156.1
Coordinates 498313..498579 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag ASZ87_RS16845 Protein ID WP_000643598.1
Coordinates 498566..498811 (+) Length 82 a.a.

Genomic Context

ASZ87_RS20655ASZ87_RS20660ASZ87_RS16795ASZ87_RS16800ASZ87_RS16805ASZ87_RS16810ASZ87_RS16815ASZ87_RS21070ASZ87_RS21075ASZ87_RS16830ASZ87_RS16835ASZ87_RS16840ASZ87_RS16845ASZ87_RS16850ASZ87_RS21080ASZ87_RS16865ASZ87_RS16870ASZ87_RS16875ASZ87_RS16880ASZ87_RS16885ASZ87_RS16890
Location: 493734..493940 (207 bp)
Type: Others
Protein ID: Protein_463
Location: 494140..494241 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 494231..494617 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 494812..495063 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 495036..495185 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 495277..495519 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 495771..496049 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 496424..496567 (144 bp)
Type: Others
Protein ID: Protein_470
Location: 496621..496659 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 496871..497338 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 497466..498128 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 498313..498579 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 498566..498811 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 498907..499701 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 499804..499932 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 499993..500175 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 500391..501395 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 501548..501907 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 502180..502413 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 502681..503187 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 503344..503730 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS20655493734..493940+207Protein_463DUF3709 domain-containing protein-
ASZ87_RS20660494140..494241+102WP_001921603.1hypothetical protein-
ASZ87_RS16795494231..494617+387WP_000703163.1VOC family protein-
ASZ87_RS16800494812..495063+252WP_001890111.1TIGR03643 family protein-
ASZ87_RS16805495036..495185+150WP_071908333.1DUF3265 domain-containing protein-
ASZ87_RS16810495277..495519+243WP_000107461.1hypothetical protein-
ASZ87_RS16815495771..496049+279WP_000280324.1DUF3709 domain-containing protein-
ASZ87_RS21070496424..496567+144Protein_470DUF645 family protein-
ASZ87_RS21075496621..496659+39WP_082798268.1hypothetical protein-
ASZ87_RS16830496871..497338+468WP_001289288.1OsmC family protein-
ASZ87_RS16835497466..498128+663WP_000960654.1hypothetical protein-
ASZ87_RS16840498313..498579+267WP_000589156.1BrnT family toxinToxin
ASZ87_RS16845498566..498811+246WP_000643598.1hypothetical proteinAntitoxin
ASZ87_RS16850498907..499701+795WP_001911581.1hypothetical protein-
ASZ87_RS21080499804..499932+129WP_071908338.1general secretion pathway protein GspI-
ASZ87_RS16865499993..500175+183WP_000923182.1DUF645 family protein-
ASZ87_RS16870500391..501395+1005WP_000964920.1LD-carboxypeptidase-
ASZ87_RS16875501548..501907+360WP_001071541.1VOC family protein-
ASZ87_RS16880502180..502413+234WP_001890112.1DUF3709 domain-containing protein-
ASZ87_RS16885502681..503187+507WP_000393074.1hypothetical protein-
ASZ87_RS16890503344..503730+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T58309 WP_000589156.1 NZ_CP013310:498313-498579 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T58309 NZ_CP013310:498313-498579 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT58309 WP_000643598.1 NZ_CP013310:498566-498811 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT58309 NZ_CP013310:498566-498811 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References