74614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 751256..751815 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag A6J62_RS03370 Protein ID WP_000578476.1
Coordinates 751537..751815 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag A6J62_RS03365 Protein ID WP_000381183.1
Coordinates 751256..751540 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS03350 749950..750363 - 414 WP_000049420.1 VOC family protein -
A6J62_RS03360 750547..751062 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
A6J62_RS03365 751256..751540 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6J62_RS03370 751537..751815 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
A6J62_RS03375 751954..752349 - 396 WP_001000867.1 hypothetical protein -
A6J62_RS03385 752600..752725 - 126 WP_001905700.1 DUF645 family protein -
A6J62_RS03390 753024..753545 - 522 WP_000921691.1 DUF2442 domain-containing protein -
A6J62_RS03395 753539..753808 - 270 WP_001114075.1 DUF4160 domain-containing protein -
A6J62_RS03400 753839..753943 - 105 WP_099607150.1 acetyltransferase -
A6J62_RS03405 754000..754599 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
A6J62_RS03410 754749..755621 - 873 WP_000254716.1 DUF3800 domain-containing protein -
A6J62_RS03415 755796..756014 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
A6J62_RS03420 756078..756515 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640
flank IS/Tn - - 756078..756515 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T74614 WP_000578476.1 NZ_CP020407:751537-751815 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T74614 NZ_CP020407:751537-751815 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT74614 WP_000381183.1 NZ_CP020407:751256-751540 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT74614 NZ_CP020407:751256-751540 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References