104341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365762..366340 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag A1552VC_RS16200 Protein ID WP_001180243.1
Coordinates 365762..366079 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag A1552VC_RS16205 Protein ID WP_000557292.1
Coordinates 366098..366340 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS16150 360953..361348 + 396 WP_000046952.1 hypothetical protein -
A1552VC_RS16155 361651..361832 + 182 Protein_348 DUF645 family protein -
A1552VC_RS16160 362009..362404 + 396 WP_000046953.1 hypothetical protein -
A1552VC_RS16165 362548..363084 + 537 WP_000644491.1 nucleotidyltransferase family protein -
A1552VC_RS16170 363381..363560 + 180 WP_001883039.1 DUF645 family protein -
A1552VC_RS16175 363756..364181 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
A1552VC_RS16180 364330..364677 + 348 WP_000933409.1 hypothetical protein -
A1552VC_RS19845 364824..365117 + 294 WP_125460920.1 hypothetical protein -
A1552VC_RS20120 365473..365568 + 96 WP_001907607.1 DUF645 family protein -
A1552VC_RS16200 365762..366079 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1552VC_RS16205 366098..366340 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A1552VC_RS16210 366582..367091 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
A1552VC_RS16215 367148..367801 + 654 WP_000226874.1 hypothetical protein -
A1552VC_RS16220 368111..368329 + 219 WP_001917086.1 DUF3709 domain-containing protein -
A1552VC_RS16225 368732..368965 + 234 WP_032482776.1 DUF3709 domain-containing protein -
A1552VC_RS16230 369390..369570 + 181 Protein_362 DUF645 family protein -
A1552VC_RS16240 369837..370124 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
A1552VC_RS16245 370135..370452 + 318 WP_001232701.1 HigA family addiction module antidote protein -
A1552VC_RS20125 370449..370559 + 111 WP_134814058.1 DUF3265 domain-containing protein -
A1552VC_RS20045 370736..370861 + 126 WP_001944767.1 DUF645 family protein -
A1552VC_RS20050 370877..370915 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T104341 WP_001180243.1 NZ_CP028895:c366079-365762 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T104341 NZ_CP028895:c366079-365762 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT104341 WP_000557292.1 NZ_CP028895:c366340-366098 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT104341 NZ_CP028895:c366340-366098 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References