23787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 986424..986952 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag VCD_RS19125 Protein ID WP_000221352.1
Coordinates 986662..986952 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag VCD_RS19120 Protein ID WP_000213183.1
Coordinates 986424..986672 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS19075 981463..981927 + 465 WP_000140244.1 hypothetical protein -
VCD_RS19080 982027..982425 - 399 WP_001882293.1 hypothetical protein -
VCD_RS19085 982581..983081 - 501 WP_000789723.1 hypothetical protein -
VCD_RS19090 983219..983749 - 531 WP_000415563.1 hypothetical protein -
VCD_RS19095 983900..984295 - 396 WP_000649527.1 DUF3465 domain-containing protein -
VCD_RS19100 984503..984928 - 426 WP_000415748.1 hypothetical protein -
VCD_RS19105 985200..985853 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
VCD_RS19120 986424..986672 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCD_RS19125 986662..986952 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCD_RS19130 987088..987603 - 516 WP_001201528.1 lipocalin family protein -
VCD_RS19135 987740..988216 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
VCD_RS20725 988244..988354 - 111 WP_071917832.1 DUF3265 domain-containing protein -
VCD_RS19140 988351..989280 - 930 WP_000335802.1 hypothetical protein -
VCD_RS19145 989400..989846 - 447 WP_000128977.1 hypothetical protein -
VCD_RS19150 989999..991003 - 1005 WP_000964925.1 LD-carboxypeptidase -
VCD_RS20895 991216..991254 - 39 WP_106019119.1 hypothetical protein -
VCD_RS20430 991270..991395 - 126 WP_001944767.1 DUF645 family protein -
VCD_RS21075 991572..991682 - 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T23787 WP_000221352.1 NC_012667:986662-986952 [Vibrio cholerae MJ-1236]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T23787 NC_012667:986662-986952 [Vibrio cholerae MJ-1236]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT23787 WP_000213183.1 NC_012667:986424-986672 [Vibrio cholerae MJ-1236]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT23787 NC_012667:986424-986672 [Vibrio cholerae MJ-1236]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References