180866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 393048..393814 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag IT766_RS15440 Protein ID WP_000982260.1
Coordinates 393048..393545 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag IT766_RS15445 Protein ID WP_000246253.1
Coordinates 393542..393814 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS15395 388490..389194 + 705 WP_000087610.1 HNH endonuclease -
IT766_RS15400 389352..389690 + 339 WP_000713853.1 hypothetical protein -
IT766_RS15405 389844..390161 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
IT766_RS15410 390180..390422 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IT766_RS15415 390666..391052 + 387 WP_001015867.1 NUDIX hydrolase -
IT766_RS15420 391109..391222 + 114 WP_001900214.1 hypothetical protein -
IT766_RS15425 391171..391452 + 282 WP_001894429.1 DUF1289 domain-containing protein -
IT766_RS15430 391710..392246 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
IT766_RS15435 392383..392898 + 516 WP_001201509.1 lipocalin family protein -
IT766_RS15440 393048..393545 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
IT766_RS15445 393542..393814 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
IT766_RS15450 394207..394332 + 126 WP_001900195.1 DUF645 family protein -
IT766_RS15455 394348..394386 + 39 WP_106019118.1 hypothetical protein -
IT766_RS15460 394582..395028 + 447 WP_000006157.1 hypothetical protein -
IT766_RS15465 395176..395445 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
IT766_RS15470 395438..395716 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IT766_RS15475 396002..396280 + 279 WP_001921601.1 DUF3709 domain-containing protein -
IT766_RS15480 396532..396738 + 207 Protein_346 DUF3709 domain-containing protein -
IT766_RS15485 396938..397039 + 102 WP_001921603.1 hypothetical protein -
IT766_RS15490 397029..397415 + 387 WP_000703163.1 VOC family protein -
IT766_RS15495 397610..397861 + 252 WP_001890111.1 TIGR03643 family protein -
IT766_RS15500 397834..397983 + 150 WP_071908333.1 DUF3265 domain-containing protein -
IT766_RS15505 398075..398317 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T180866 WP_000982260.1 NZ_CP064351:c393545-393048 [Vibrio cholerae C6706]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T180866 NZ_CP085767:c138900-138547 [Enterobacter hormaechei]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTATTGCGGGAAAAGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAATTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCAATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGATCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT180866 WP_000246253.1 NZ_CP064351:c393814-393542 [Vibrio cholerae C6706]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT180866 NZ_CP085767:c138542-138240 [Enterobacter hormaechei]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGGCGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTGCCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References