Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 382221..383314 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag AN947_RS02165 Protein ID WP_000351248.1
Coordinates 382913..383314 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AN947_RS02160 Protein ID WP_001047169.1
Coordinates 382221..382913 (+) Length 231 a.a.

Genomic Context

AN947_RS02085AN947_RS20775AN947_RS02090AN947_RS02105AN947_RS02110AN947_RS02125AN947_RS02130AN947_RS02140AN947_RS20780AN947_RS02155AN947_RS02160AN947_RS02165AN947_RS02170AN947_RS02175AN947_RS02180AN947_RS02185AN947_RS02190AN947_RS02200AN947_RS02225AN947_RS02230AN947_RS02150AN947_RS02210AN947_RS02215
Location: 377504..377881 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 377938..378052 (115 bp)
Type: Others
Protein ID: Protein_378
Location: 378001..378282 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 378448..378561 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 378510..378737 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 379078..379410 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 379397..379711 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 379848..380282 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 380450..380605 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 381778..382084 (307 bp)
Type: Others
Protein ID: Protein_387
Location: 382221..382913 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 382913..383314 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 383284..383427 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 383502..383915 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 384129..384380 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 384370..384657 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 384785..385240 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 385562..385714 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 386913..387581 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 387733..388020 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 380730..381710 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 385916..386413 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 386410..386682 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AN947_RS02085377504..377881+378WP_000411109.1hypothetical protein-
AN947_RS20775377938..378052+115Protein_378acetyltransferase-
AN947_RS02090378001..378282+282WP_001894453.1DUF1289 domain-containing protein-
AN947_RS02105378448..378561+114WP_001889158.1hypothetical protein-
AN947_RS02110378510..378737+228WP_001894457.1DUF1289 domain-containing protein-
AN947_RS02125379078..379410+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
AN947_RS02130379397..379711+315WP_000071008.1DNA-binding transcriptional regulator-
AN947_RS02140379848..380282+435WP_000256036.1GNAT family N-acetyltransferase-
AN947_RS20780380450..380605+156WP_000751734.1hypothetical protein-
AN947_RS02150380730..381710-981WP_000019370.1IS5-like element ISVch5 family transposase-
AN947_RS02155381778..382084+307Protein_387CatB-related O-acetyltransferase-
AN947_RS02160382221..382913+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
AN947_RS02165382913..383314+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
AN947_RS02170383284..383427+144WP_071908341.1DUF3265 domain-containing protein-
AN947_RS02175383502..383915+414WP_000049417.1VOC family protein-
AN947_RS02180384129..384380+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AN947_RS02185384370..384657+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
AN947_RS02190384785..385240+456WP_001245327.1GNAT family N-acetyltransferase-
AN947_RS02200385562..385714+153WP_001884520.1DUF645 family protein-
AN947_RS02210385916..386413-498WP_000982260.1GNAT family N-acetyltransferase-
AN947_RS02215386410..386682-273WP_000246253.1DUF1778 domain-containing protein-
AN947_RS02225386913..387581+669WP_000043871.1hypothetical protein-
AN947_RS02230387733..388020+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791
flankIS/Tn--380730..381710980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T56918 WP_000351248.1 NZ_CP012666:382913-383314 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T56918 NZ_CP012666:382913-383314 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT56918 WP_001047169.1 NZ_CP012666:382221-382913 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT56918 NZ_CP012666:382221-382913 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References