Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 350039..350577 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag J9265_RS15425 Protein ID WP_000802136.1
Coordinates 350039..350338 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag J9265_RS15430 Protein ID WP_001107719.1
Coordinates 350335..350577 (-) Length 81 a.a.

Genomic Context

J9265_RS19055J9265_RS15385J9265_RS15390J9265_RS15395J9265_RS15400J9265_RS15405J9265_RS15410J9265_RS15415J9265_RS15420J9265_RS15435J9265_RS15440J9265_RS15445J9265_RS15450J9265_RS15455J9265_RS15460J9265_RS15465J9265_RS15425J9265_RS15430
Location: 345776..345913 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 345974..346156 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 346356..346829 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346844..346936 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 346978..347604 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347727..348425 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 348456..348545 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 349123..349302 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 349516..349911 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 350806..351384 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 351406..351498 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 351922..352605 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 352819..353085 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 353240..353839 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 354120..355055 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 355021..355161 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 350039..350338 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 350335..350577 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J9265_RS19055345776..345913+138WP_001890145.1hypothetical protein-
J9265_RS15385 (J9265_15385)345974..346156+183WP_000923182.1DUF645 family protein-
J9265_RS15390 (J9265_15390)346356..346829+474WP_001161076.1GrpB family protein-
J9265_RS15395 (J9265_15395)346844..346936+93WP_014378730.1DUF3265 domain-containing protein-
J9265_RS15400 (J9265_15400)346978..347604+627WP_000365424.1LysE family translocator-
J9265_RS15405 (J9265_15405)347727..348425+699WP_001890502.1hypothetical protein-
J9265_RS15410 (J9265_15410)348456..348545+90WP_072606010.1DUF3265 domain-containing protein-
J9265_RS15415 (J9265_15415)349123..349302+180WP_001883058.1DUF645 family protein-
J9265_RS15420 (J9265_15420)349516..349911+396WP_000870857.1DUF3465 domain-containing protein-
J9265_RS15425 (J9265_15425)350039..350338-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
J9265_RS15430 (J9265_15430)350335..350577-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
J9265_RS15435 (J9265_15435)350806..351384+579WP_000110120.1hypothetical protein-
J9265_RS15440 (J9265_15440)351406..351498+93WP_014164112.1DUF3265 domain-containing protein-
J9265_RS15445 (J9265_15445)351922..352605+684WP_000877436.1hypothetical protein-
J9265_RS15450 (J9265_15450)352819..353085+267WP_000937852.1hypothetical protein-
J9265_RS15455 (J9265_15455)353240..353839+600WP_000429495.1DUF6338 family protein-
J9265_RS15460 (J9265_15460)354120..355055+936WP_000051985.1restriction endonuclease-
J9265_RS15465 (J9265_15465)355021..355161+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T198983 WP_000802136.1 NZ_CP072848:c350338-350039 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T198983 NZ_CP097079:c4820500-4819583 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT198983 WP_001107719.1 NZ_CP072848:c350577-350335 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT198983 NZ_CP097079:c4821264-4820506 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References