Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 363424..363952 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag LVJ30_RS15680 Protein ID WP_000221352.1
Coordinates 363424..363714 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag LVJ30_RS15685 Protein ID WP_000213183.1
Coordinates 363704..363952 (-) Length 83 a.a.

Genomic Context

LVJ30_RS15630LVJ30_RS15635LVJ30_RS15640LVJ30_RS15645LVJ30_RS15650LVJ30_RS15655LVJ30_RS15660LVJ30_RS15665LVJ30_RS15670LVJ30_RS15675LVJ30_RS15690LVJ30_RS15695LVJ30_RS15700LVJ30_RS15705LVJ30_RS15710LVJ30_RS15715LVJ30_RS15680LVJ30_RS15685LVJ30_RS15720
Location: 358694..358804 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 358843..358953 (111 bp)
Type: Others
Protein ID: Protein_360
Location: 358981..359106 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 359069..359185 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 359373..360377 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 360530..360976 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 361096..362025 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 362022..362132 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 362160..362636 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 362827..363288 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 364523..365176 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 365448..365873 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 366081..366476 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 366627..367157 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 367295..367795 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 367951..368349 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 363424..363714 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 363704..363952 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 368449..368913 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15630 (LVJ30_15635)358694..358804+111WP_134814058.1DUF3265 domain-containing protein-
LVJ30_RS15635 (LVJ30_15640)358843..358953+111Protein_360acetyltransferase-
LVJ30_RS15640 (LVJ30_15645)358981..359106+126WP_001944767.1DUF645 family protein-
LVJ30_RS15645 (LVJ30_15650)359069..359185+117WP_001889170.1hypothetical protein-
LVJ30_RS15650 (LVJ30_15655)359373..360377+1005WP_000964925.1LD-carboxypeptidase-
LVJ30_RS15655 (LVJ30_15660)360530..360976+447WP_000128977.1hypothetical protein-
LVJ30_RS15660 (LVJ30_15665)361096..362025+930WP_000335802.1hypothetical protein-
LVJ30_RS15665 (LVJ30_15670)362022..362132+111WP_071917832.1DUF3265 domain-containing protein-
LVJ30_RS15670 (LVJ30_15675)362160..362636+477WP_001047180.1GNAT family N-acetyltransferase-
LVJ30_RS15675 (LVJ30_15680)362827..363288+462WP_001903091.1lipocalin family protein-
LVJ30_RS15680 (LVJ30_15685)363424..363714-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LVJ30_RS15685 (LVJ30_15690)363704..363952-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LVJ30_RS15690 (LVJ30_15695)364523..365176+654WP_000036957.1site-specific DNA-methyltransferase-
LVJ30_RS15695 (LVJ30_15700)365448..365873+426WP_000415748.1hypothetical protein-
LVJ30_RS15700 (LVJ30_15705)366081..366476+396WP_000649527.1DUF3465 domain-containing protein-
LVJ30_RS15705 (LVJ30_15710)366627..367157+531WP_000415563.1hypothetical protein-
LVJ30_RS15710 (LVJ30_15715)367295..367795+501WP_000789723.1hypothetical protein-
LVJ30_RS15715 (LVJ30_15720)367951..368349+399WP_001882293.1hypothetical protein-
LVJ30_RS15720 (LVJ30_15725)368449..368913-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T230522 WP_000221352.1 NZ_CP090379:c363714-363424 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T230522 NZ_CP124916:2802922-2803065 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT230522 WP_000213183.1 NZ_CP090379:c363952-363704 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT230522 NZ_CP124916:c2803259-2802997 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References