87031

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 429088..429492 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag CSW01_RS16830 Protein ID WP_001114075.1
Coordinates 429223..429492 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CSW01_RS16825 Protein ID WP_099607150.1
Coordinates 429088..429192 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS16790 424589..425506 + 918 WP_000186333.1 alpha/beta hydrolase -
CSW01_RS16795 425663..426052 + 390 WP_001081302.1 hypothetical protein -
CSW01_RS16800 426188..426397 + 210 Protein_463 GNAT family N-acetyltransferase -
CSW01_RS16805 426516..426953 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
CSW01_RS16810 427017..427235 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
CSW01_RS16815 427410..428282 + 873 WP_000254716.1 DUF3800 domain-containing protein -
CSW01_RS16820 428432..429031 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
CSW01_RS16825 429088..429192 + 105 WP_099607150.1 acetyltransferase Antitoxin
CSW01_RS16830 429223..429492 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
CSW01_RS16835 429486..430007 + 522 WP_000921691.1 DUF2442 domain-containing protein -
CSW01_RS16845 430306..430431 + 126 WP_001905700.1 DUF645 family protein -
CSW01_RS16855 430682..431077 + 396 WP_001000867.1 hypothetical protein -
CSW01_RS16860 431216..431494 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
CSW01_RS16865 431491..431775 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CSW01_RS16870 431969..432484 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
CSW01_RS16880 432668..433081 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262
flank IS/Tn - - 426516..426953 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T87031 WP_001114075.1 NZ_CP024163:429223-429492 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T87031 NZ_CP024163:429223-429492 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT87031 WP_099607150.1 NZ_CP024163:429088-429192 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT87031 NZ_CP024163:429088-429192 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References