Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 429088..429492 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag CSW01_RS16830 Protein ID WP_001114075.1
Coordinates 429223..429492 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CSW01_RS16825 Protein ID WP_099607150.1
Coordinates 429088..429192 (+) Length 35 a.a.

Genomic Context

CSW01_RS16790CSW01_RS16795CSW01_RS16800CSW01_RS16805CSW01_RS16810CSW01_RS16815CSW01_RS16820CSW01_RS16825CSW01_RS16830CSW01_RS16835CSW01_RS16845CSW01_RS16855CSW01_RS16870CSW01_RS16880CSW01_RS16860CSW01_RS16865
Location: 424589..425506 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 425663..426052 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 426188..426397 (210 bp)
Type: Others
Protein ID: Protein_463
Location: 426516..426953 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 427017..427235 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 427410..428282 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 428432..429031 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 429088..429192 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 429223..429492 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 429486..430007 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 430306..430431 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 430682..431077 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 431969..432484 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 432668..433081 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 431216..431494 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 431491..431775 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS16790424589..425506+918WP_000186333.1alpha/beta hydrolase-
CSW01_RS16795425663..426052+390WP_001081302.1hypothetical protein-
CSW01_RS16800426188..426397+210Protein_463GNAT family N-acetyltransferase-
CSW01_RS16805426516..426953+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
CSW01_RS16810427017..427235+219WP_071908318.1GNAT family N-acetyltransferase-
CSW01_RS16815427410..428282+873WP_000254716.1DUF3800 domain-containing protein-
CSW01_RS16820428432..429031+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
CSW01_RS16825429088..429192+105WP_099607150.1acetyltransferaseAntitoxin
CSW01_RS16830429223..429492+270WP_001114075.1DUF4160 domain-containing proteinToxin
CSW01_RS16835429486..430007+522WP_000921691.1DUF2442 domain-containing protein-
CSW01_RS16845430306..430431+126WP_001905700.1DUF645 family protein-
CSW01_RS16855430682..431077+396WP_001000867.1hypothetical protein-
CSW01_RS16860431216..431494-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
CSW01_RS16865431491..431775-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
CSW01_RS16870431969..432484+516WP_000343779.1GNAT family N-acetyltransferase-
CSW01_RS16880432668..433081+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262
flankIS/Tn--426516..426953437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T87031 WP_001114075.1 NZ_CP024163:429223-429492 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T87031 NZ_CP024163:429223-429492 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT87031 WP_099607150.1 NZ_CP024163:429088-429192 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT87031 NZ_CP024163:429088-429192 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References