Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 972179..972945 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag DG247_RS19135 Protein ID WP_000982260.1
Coordinates 972448..972945 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag DG247_RS19130 Protein ID WP_000246253.1
Coordinates 972179..972451 (+) Length 91 a.a.

Genomic Context

DG247_RS19100DG247_RS19105DG247_RS19130DG247_RS19135DG247_RS19175DG247_RS19180DG247_RS19060DG247_RS19065DG247_RS19070DG247_RS19075DG247_RS19080DG247_RS19085DG247_RS19090DG247_RS19110DG247_RS19120DG247_RS19125DG247_RS19140DG247_RS19145DG247_RS19160DG247_RS19165DG247_RS19170DG247_RS19190DG247_RS19195
Location: 970277..970555 (279 bp)
Type: Others
Protein ID: WP_001258569.1
Location: 970548..970817 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 972179..972451 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 972448..972945 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 975571..975813 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 975832..976149 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 967676..967918 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 968010..968159 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 968132..968383 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 968578..968964 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 968954..969055 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 969255..969461 (207 bp)
Type: Others
Protein ID: Protein_884
Location: 969713..969991 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 970965..971411 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 971607..971645 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 971661..971786 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 973095..973610 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 973747..974283 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 974541..974822 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 974771..974884 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 974941..975327 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 976303..976641 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 976799..977503 (705 bp)
Type: Others
Protein ID: WP_000087610.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS19060967676..967918-243WP_000107461.1hypothetical protein-
DG247_RS19065968010..968159-150WP_071908333.1DUF3265 domain-containing protein-
DG247_RS19070968132..968383-252WP_001890111.1TIGR03643 family protein-
DG247_RS19075968578..968964-387WP_000703163.1VOC family protein-
DG247_RS19080968954..969055-102WP_001921603.1hypothetical protein-
DG247_RS19085969255..969461-207Protein_884DUF3709 domain-containing protein-
DG247_RS19090969713..969991-279WP_001921601.1DUF3709 domain-containing protein-
DG247_RS19100970277..970555+279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
DG247_RS19105970548..970817+270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
DG247_RS19110970965..971411-447WP_000006157.1hypothetical protein-
DG247_RS19120971607..971645-39WP_106019118.1hypothetical protein-
DG247_RS19125971661..971786-126WP_001900195.1DUF645 family protein-
DG247_RS19130972179..972451+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
DG247_RS19135972448..972945+498WP_000982260.1GNAT family N-acetyltransferaseToxin
DG247_RS19140973095..973610-516WP_001201509.1lipocalin family protein-
DG247_RS19145973747..974283-537WP_000469482.1GNAT family N-acetyltransferase-
DG247_RS19160974541..974822-282WP_001894429.1DUF1289 domain-containing protein-
DG247_RS19165974771..974884-114WP_001900214.1hypothetical protein-
DG247_RS19170974941..975327-387WP_001015867.1NUDIX hydrolase-
DG247_RS19175975571..975813+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG247_RS19180975832..976149+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS19190976303..976641-339WP_000713853.1hypothetical protein-
DG247_RS19195976799..977503-705WP_000087610.1HNH endonuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T294363 WP_000982260.1 NZ_LT992487:972448-972945 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT294363 WP_000246253.1 NZ_LT992487:972179-972451 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References