87027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 418181..418709 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag CSW01_RS16715 Protein ID WP_000221354.1
Coordinates 418422..418709 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag CSW01_RS16710 Protein ID WP_001250179.1
Coordinates 418181..418432 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS16665 413449..413763 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
CSW01_RS16675 413900..414334 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
CSW01_RS19850 414502..414657 + 156 WP_000751734.1 hypothetical protein -
CSW01_RS16680 414782..415762 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
CSW01_RS16685 415830..416136 + 307 Protein_443 CatB-related O-acetyltransferase -
CSW01_RS16690 416273..416965 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
CSW01_RS16695 416965..417366 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
CSW01_RS16700 417336..417479 + 144 WP_071908341.1 DUF3265 domain-containing protein -
CSW01_RS16705 417554..417967 + 414 WP_000049417.1 VOC family protein -
CSW01_RS16710 418181..418432 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSW01_RS16715 418422..418709 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSW01_RS16720 418837..419292 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
CSW01_RS16725 419614..419766 + 153 WP_001884520.1 DUF645 family protein -
CSW01_RS16735 419968..420465 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
CSW01_RS16740 420462..420734 - 273 WP_000246253.1 DUF1778 domain-containing protein -
CSW01_RS16750 420965..421633 + 669 WP_000043871.1 hypothetical protein -
CSW01_RS16755 421785..422072 + 288 WP_000426470.1 hypothetical protein -
CSW01_RS16760 422213..422584 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
CSW01_RS20000 422651..423076 + 426 WP_001882332.1 DUF1778 domain-containing protein -
CSW01_RS16770 423073..423606 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262
flank IS/Tn - - 414782..415762 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T87027 WP_000221354.1 NZ_CP024163:418422-418709 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T87027 NZ_CP024163:418422-418709 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT87027 WP_001250179.1 NZ_CP024163:418181-418432 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT87027 NZ_CP024163:418181-418432 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References