Detailed information of TA system TA046762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 126249..127204
• Replicon: chromosome
• Accession: NZ_CP007635
• Organism: Vibrio cholerae strain 2012EL-2176

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: EN18_RS15000
• Protein ID: WP_000118351.1
• Coordinates: 126671..127204 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EN18_RS14995
• Protein ID: WP_001882332.1
• Coordinates: 126249..126674 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EN18_RS14950	121779..122030	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EN18_RS14955	122020..122307	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EN18_RS14960	122435..122890	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
EN18_RS14965	123212..123364	+	153	WP_001884520.1	DUF645 family protein	-
EN18_RS14970	123566..124063	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
EN18_RS14975	124060..124332	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
EN18_RS14980	124563..125231	+	669	WP_000043871.1	hypothetical protein	-
EN18_RS14985	125383..125670	+	288	WP_000426470.1	hypothetical protein	-
EN18_RS14990	125811..126182	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
EN18_RS14995	126249..126674	+	426	WP_001882332.1	DUF1778 domain-containing protein	Antitoxin
EN18_RS15000	126671..127204	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
EN18_RS15005	127406..127663	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EN18_RS15010	127651..127953	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EN18_RS15015	128187..129104	+	918	WP_000186333.1	alpha/beta hydrolase	-
EN18_RS15020	129261..129650	+	390	WP_001081302.1	hypothetical protein	-
EN18_RS15025	129786..129995	+	210	Protein_203	GNAT family N-acetyltransferase	-
EN18_RS15030	130114..130551	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
EN18_RS15035	130615..130833	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
EN18_RS15040	131008..131880	+	873	WP_000254716.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	31037..137542	106505
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	36117..137166	101049
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	130114..130551	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (57-133)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T46762 WP_000118351.1 NZ_CP007635:126671-127204 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T46762 NZ_CP007635:126671-127204 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15714.41 Da
• Isoelectric Point: 7.6659

>AT46762 WP_001882332.1 NZ_CP007635:126249-126674 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 426 bp

>AT46762 NZ_CP007635:126249-126674 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Structures

Toxin

• AlphaFold DB: Q9KM94