Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 126249..127204 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag EN18_RS15000 Protein ID WP_000118351.1
Coordinates 126671..127204 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EN18_RS14995 Protein ID WP_001882332.1
Coordinates 126249..126674 (+) Length 142 a.a.

Genomic Context

EN18_RS14950EN18_RS14955EN18_RS14960EN18_RS14965EN18_RS14980EN18_RS14985EN18_RS14990EN18_RS14995EN18_RS15000EN18_RS15005EN18_RS15010EN18_RS15015EN18_RS15020EN18_RS15025EN18_RS15030EN18_RS15035EN18_RS15040EN18_RS14970EN18_RS14975
Location: 121779..122030 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 122020..122307 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 122435..122890 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 123212..123364 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 124563..125231 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 125383..125670 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 125811..126182 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 126249..126674 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 126671..127204 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 127406..127663 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 127651..127953 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 128187..129104 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 129261..129650 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 129786..129995 (210 bp)
Type: Others
Protein ID: Protein_203
Location: 130114..130551 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 130615..130833 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 131008..131880 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 123566..124063 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 124060..124332 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS14950121779..122030+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EN18_RS14955122020..122307+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
EN18_RS14960122435..122890+456WP_001245327.1GNAT family N-acetyltransferase-
EN18_RS14965123212..123364+153WP_001884520.1DUF645 family protein-
EN18_RS14970123566..124063-498WP_000982260.1GNAT family N-acetyltransferase-
EN18_RS14975124060..124332-273WP_000246253.1DUF1778 domain-containing protein-
EN18_RS14980124563..125231+669WP_000043871.1hypothetical protein-
EN18_RS14985125383..125670+288WP_000426470.1hypothetical protein-
EN18_RS14990125811..126182+372WP_001164080.1nucleotide pyrophosphohydrolase-
EN18_RS14995126249..126674+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
EN18_RS15000126671..127204+534WP_000118351.1GNAT family N-acetyltransferaseToxin
EN18_RS15005127406..127663+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EN18_RS15010127651..127953+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
EN18_RS15015128187..129104+918WP_000186333.1alpha/beta hydrolase-
EN18_RS15020129261..129650+390WP_001081302.1hypothetical protein-
EN18_RS15025129786..129995+210Protein_203GNAT family N-acetyltransferase-
EN18_RS15030130114..130551+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
EN18_RS15035130615..130833+219WP_071908318.1GNAT family N-acetyltransferase-
EN18_RS15040131008..131880+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049
flankIS/Tn--130114..130551437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T46762 WP_000118351.1 NZ_CP007635:126671-127204 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T46762 NZ_CP007635:126671-127204 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT46762 WP_001882332.1 NZ_CP007635:126249-126674 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT46762 NZ_CP007635:126249-126674 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References