26144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 325857..326623 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag O3Y_RS15460 Protein ID WP_000982260.1
Coordinates 325857..326354 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag O3Y_RS15465 Protein ID WP_000246253.1
Coordinates 326351..326623 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS15415 321299..322003 + 705 WP_000087610.1 HNH endonuclease -
O3Y_RS15420 322161..322499 + 339 WP_000713853.1 hypothetical protein -
O3Y_RS15425 322653..322970 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
O3Y_RS15430 322989..323231 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
O3Y_RS15435 323475..323861 + 387 WP_001015867.1 NUDIX hydrolase -
O3Y_RS19615 323918..324031 + 114 WP_001900214.1 hypothetical protein -
O3Y_RS15440 323980..324261 + 282 WP_001894429.1 DUF1289 domain-containing protein -
O3Y_RS15450 324519..325055 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
O3Y_RS15455 325192..325707 + 516 WP_001201510.1 lipocalin family protein -
O3Y_RS15460 325857..326354 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
O3Y_RS15465 326351..326623 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
O3Y_RS20140 327016..327141 + 126 WP_001900195.1 DUF645 family protein -
O3Y_RS20145 327157..327195 + 39 WP_106019118.1 hypothetical protein -
O3Y_RS15475 327391..327837 + 447 WP_000006157.1 hypothetical protein -
O3Y_RS15480 327985..328254 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
O3Y_RS15485 328247..328525 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
O3Y_RS19625 328811..329089 + 279 WP_001921601.1 DUF3709 domain-containing protein -
O3Y_RS20160 329341..329547 + 207 Protein_292 DUF3709 domain-containing protein -
O3Y_RS20165 329747..329848 + 102 WP_001921603.1 hypothetical protein -
O3Y_RS15490 329838..330224 + 387 WP_000703163.1 VOC family protein -
O3Y_RS15495 330419..330670 + 252 WP_001890111.1 TIGR03643 family protein -
O3Y_RS19635 330643..330792 + 150 WP_071908333.1 DUF3265 domain-containing protein -
O3Y_RS15500 330884..331126 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T26144 WP_000982260.1 NC_016945:c326354-325857 [Vibrio cholerae IEC224]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T26144 NC_016945:c326354-325857 [Vibrio cholerae IEC224]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT26144 WP_000246253.1 NC_016945:c326623-326351 [Vibrio cholerae IEC224]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT26144 NC_016945:c326623-326351 [Vibrio cholerae IEC224]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References