58349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 332151..332710 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ79_RS15710 Protein ID WP_000578476.1
Coordinates 332151..332429 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ79_RS15715 Protein ID WP_000381183.1
Coordinates 332426..332710 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS15665 328091..328273 + 183 WP_000923340.1 DUF645 family protein -
ASZ79_RS15670 328488..329027 + 540 WP_000099372.1 hypothetical protein -
ASZ79_RS15675 329150..329665 + 516 WP_000090011.1 hypothetical protein -
ASZ79_RS15680 329800..330336 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ79_RS15685 330805..330915 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ79_RS15695 331128..331280 + 153 WP_001884520.1 DUF645 family protein -
ASZ79_RS15700 331564..332007 + 444 WP_000803902.1 hypothetical protein -
ASZ79_RS15705 332011..332121 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ79_RS15710 332151..332429 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ASZ79_RS15715 332426..332710 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ79_RS15725 332886..333185 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ79_RS15730 333182..333424 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
ASZ79_RS15740 333843..333920 + 78 WP_071908337.1 DUF645 family protein -
ASZ79_RS20905 333924..333950 + 27 Protein_298 hypothetical protein -
ASZ79_RS20985 334536..334679 + 144 WP_001900215.1 hypothetical protein -
ASZ79_RS20480 334773..334952 + 180 Protein_300 DUF645 family protein -
ASZ79_RS15765 335170..335598 + 429 WP_000620002.1 N-acetyltransferase -
ASZ79_RS15775 336186..336668 + 483 WP_000422940.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58349 WP_000578476.1 NZ_CP013314:c332429-332151 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58349 NZ_CP013314:c332429-332151 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58349 WP_000381183.1 NZ_CP013314:c332710-332426 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58349 NZ_CP013314:c332710-332426 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References