Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 419998..420526 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag FY484_RS16420 Protein ID WP_000221354.1
Coordinates 420239..420526 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag FY484_RS16415 Protein ID WP_001250179.1
Coordinates 419998..420249 (+) Length 84 a.a.

Genomic Context

FY484_RS16375FY484_RS16380FY484_RS19565FY484_RS16390FY484_RS16395FY484_RS16400FY484_RS16405FY484_RS16410FY484_RS16415FY484_RS16420FY484_RS16425FY484_RS16430FY484_RS16450FY484_RS16455FY484_RS16460FY484_RS19570FY484_RS16470FY484_RS16385FY484_RS16440FY484_RS16445
Location: 415266..415580 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 415717..416151 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416319..416474 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 417647..417953 (307 bp)
Type: Others
Protein ID: Protein_446
Location: 418090..418782 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 418782..419183 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419153..419296 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419371..419784 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 419998..420249 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 420239..420526 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 420654..421109 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421431..421583 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422782..423450 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423602..423889 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424030..424401 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424468..424893 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 424890..425423 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 416599..417579 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 421785..422282 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422279..422551 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS16375415266..415580+315WP_000071008.1DNA-binding transcriptional regulator-
FY484_RS16380415717..416151+435WP_000256036.1GNAT family N-acetyltransferase-
FY484_RS19565416319..416474+156WP_000751734.1hypothetical protein-
FY484_RS16385416599..417579-981WP_000019370.1IS5-like element ISVch5 family transposase-
FY484_RS16390417647..417953+307Protein_446CatB-related O-acetyltransferase-
FY484_RS16395418090..418782+693WP_001047169.1GNAT family N-acetyltransferase-
FY484_RS16400418782..419183+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
FY484_RS16405419153..419296+144WP_071908341.1DUF3265 domain-containing protein-
FY484_RS16410419371..419784+414WP_000049417.1VOC family protein-
FY484_RS16415419998..420249+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FY484_RS16420420239..420526+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FY484_RS16425420654..421109+456WP_001245327.1GNAT family N-acetyltransferase-
FY484_RS16430421431..421583+153WP_001884520.1DUF645 family protein-
FY484_RS16440421785..422282-498WP_000982260.1GNAT family N-acetyltransferase-
FY484_RS16445422279..422551-273WP_000246253.1DUF1778 domain-containing protein-
FY484_RS16450422782..423450+669WP_000043871.1hypothetical protein-
FY484_RS16455423602..423889+288WP_000426470.1hypothetical protein-
FY484_RS16460424030..424401+372WP_001164080.1nucleotide pyrophosphohydrolase-
FY484_RS19570424468..424893+426WP_001882332.1DUF1778 domain-containing protein-
FY484_RS16470424890..425423+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639
flankIS/Tn--416599..417579980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T293803 WP_000221354.1 NZ_LT906615:420239-420526 [Vibrio cholerae O1 biovar El Tor str. N16961]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT293803 WP_001250179.1 NZ_LT906615:419998-420249 [Vibrio cholerae O1 biovar El Tor str. N16961]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References