56923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 395036..395440 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag AN947_RS02310 Protein ID WP_001114075.1
Coordinates 395171..395440 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AN947_RS20790 Protein ID WP_099607150.1
Coordinates 395036..395140 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS02270 390537..391454 + 918 WP_000186333.1 alpha/beta hydrolase -
AN947_RS02280 391611..392000 + 390 WP_001081302.1 hypothetical protein -
AN947_RS02285 392136..392345 + 210 Protein_407 GNAT family N-acetyltransferase -
AN947_RS02290 392464..392901 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
AN947_RS02295 392965..393183 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
AN947_RS02300 393358..394230 + 873 WP_000254716.1 DUF3800 domain-containing protein -
AN947_RS02305 394380..394979 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
AN947_RS20790 395036..395140 + 105 WP_099607150.1 acetyltransferase Antitoxin
AN947_RS02310 395171..395440 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
AN947_RS02315 395434..395955 + 522 WP_000921691.1 DUF2442 domain-containing protein -
AN947_RS02325 396254..396379 + 126 WP_001905700.1 DUF645 family protein -
AN947_RS02335 396630..397025 + 396 WP_001000867.1 hypothetical protein -
AN947_RS02340 397164..397442 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
AN947_RS02345 397439..397723 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
AN947_RS02350 397917..398432 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
AN947_RS02355 398616..399029 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791
flank IS/Tn - - 392464..392901 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T56923 WP_001114075.1 NZ_CP012666:395171-395440 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T56923 NZ_CP012666:395171-395440 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT56923 WP_099607150.1 NZ_CP012666:395036-395140 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT56923 NZ_CP012666:395036-395140 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References