Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 357996..358524 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GPY07_RS16065 Protein ID WP_000221352.1
Coordinates 358234..358524 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GPY07_RS16060 Protein ID WP_000213183.1
Coordinates 357996..358244 (+) Length 83 a.a.

Genomic Context

GPY07_RS16015GPY07_RS16060GPY07_RS16065GPY07_RS16020GPY07_RS16025GPY07_RS16030GPY07_RS16035GPY07_RS16040GPY07_RS16045GPY07_RS16070GPY07_RS16075GPY07_RS16080GPY07_RS16085GPY07_RS16090GPY07_RS16095GPY07_RS16100GPY07_RS16105GPY07_RS19445
Location: 353035..353499 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 357996..358244 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 358234..358524 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 353599..353997 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 354153..354653 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 354791..355321 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 355472..355867 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 356075..356500 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 356772..357425 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 358660..359175 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 359312..359788 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 359816..359926 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 359923..360852 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 360972..361418 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 361571..362575 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 362788..362826 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 362842..362967 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 363144..363254 (111 bp)
Type: Others
Protein ID: WP_134814058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS16015353035..353499+465WP_000140244.1hypothetical protein-
GPY07_RS16020353599..353997-399WP_001882293.1hypothetical protein-
GPY07_RS16025354153..354653-501WP_000789723.1hypothetical protein-
GPY07_RS16030354791..355321-531WP_000415563.1hypothetical protein-
GPY07_RS16035355472..355867-396WP_000649527.1DUF3465 domain-containing protein-
GPY07_RS16040356075..356500-426WP_000415748.1hypothetical protein-
GPY07_RS16045356772..357425-654WP_000036957.1site-specific DNA-methyltransferase-
GPY07_RS16060357996..358244+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GPY07_RS16065358234..358524+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GPY07_RS16070358660..359175-516WP_001201528.1lipocalin family protein-
GPY07_RS16075359312..359788-477WP_001047180.1GNAT family N-acetyltransferase-
GPY07_RS16080359816..359926-111WP_071917832.1DUF3265 domain-containing protein-
GPY07_RS16085359923..360852-930WP_000335802.1hypothetical protein-
GPY07_RS16090360972..361418-447WP_000128977.1hypothetical protein-
GPY07_RS16095361571..362575-1005WP_000964925.1LD-carboxypeptidase-
GPY07_RS16100362788..362826-39WP_106019119.1hypothetical protein-
GPY07_RS16105362842..362967-126WP_001944767.1DUF645 family protein-
GPY07_RS19445363144..363254-111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145065 WP_000221352.1 NZ_CP046841:358234-358524 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145065 NZ_CP062252:c5401322-5400978 [Pseudomonas allokribbensis]
ATGAGAACAATATTCTTTGAAACCACACTGTTCACCGCAAACCTGGGTCATTACCTCACGGACGACGAATATCGTGAGCT
ACAGACCTACATGCAGAGCAATCCGCATGCAGGCGATGTCATGCCACGAACCGGTGGCTTCCGAAAACTGCGTTGGGCGG
ATGCTCGTCGTGGTAAAGGCAGGAGAGGCGGCTTGCGAGTTATCTATTATTGGCTTATGAATGATGGCCAGTTTTGGATG
TTTGCGATTTATGACAAAGATGAGCTTGAGAATTTGACCGCCGATCAAGAGAGGGCGCTCAAGGGAGCCATAGAGAAAGA
GTTGAAAACACGAGGTACCCCATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145065 WP_000213183.1 NZ_CP046841:357996-358244 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145065 NZ_CP062252:c5400981-5400667 [Pseudomonas allokribbensis]
ATGAAAAAACGCGACCTGTTTGCAGAATTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATCACGCT
ACGTAATACGACACTTGAGGACAAACCAGCCCCCGAAGTCGCTGCTCAGGAAATCGTAGCGTTACGGGAAAAACTGCACA
TGTCACAGGCAGTTTTTGCCAGACGAATCAGGACAAGTCCAAGCACCCTCAGAAACTGGGAGCAGGAGAAATCAAAGCCC
AACGCTCAGGCTGCCTTGCTGATCCGTTTGGTGGAAAAATTCCCTGACATGGTCGAGCGACTGAGCGCTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References