145065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 357996..358524 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GPY07_RS16065 Protein ID WP_000221352.1
Coordinates 358234..358524 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GPY07_RS16060 Protein ID WP_000213183.1
Coordinates 357996..358244 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS16015 353035..353499 + 465 WP_000140244.1 hypothetical protein -
GPY07_RS16020 353599..353997 - 399 WP_001882293.1 hypothetical protein -
GPY07_RS16025 354153..354653 - 501 WP_000789723.1 hypothetical protein -
GPY07_RS16030 354791..355321 - 531 WP_000415563.1 hypothetical protein -
GPY07_RS16035 355472..355867 - 396 WP_000649527.1 DUF3465 domain-containing protein -
GPY07_RS16040 356075..356500 - 426 WP_000415748.1 hypothetical protein -
GPY07_RS16045 356772..357425 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
GPY07_RS16060 357996..358244 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY07_RS16065 358234..358524 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY07_RS16070 358660..359175 - 516 WP_001201528.1 lipocalin family protein -
GPY07_RS16075 359312..359788 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
GPY07_RS16080 359816..359926 - 111 WP_071917832.1 DUF3265 domain-containing protein -
GPY07_RS16085 359923..360852 - 930 WP_000335802.1 hypothetical protein -
GPY07_RS16090 360972..361418 - 447 WP_000128977.1 hypothetical protein -
GPY07_RS16095 361571..362575 - 1005 WP_000964925.1 LD-carboxypeptidase -
GPY07_RS16100 362788..362826 - 39 WP_106019119.1 hypothetical protein -
GPY07_RS16105 362842..362967 - 126 WP_001944767.1 DUF645 family protein -
GPY07_RS19445 363144..363254 - 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145065 WP_000221352.1 NZ_CP046841:358234-358524 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145065 NZ_CP062252:c5401322-5400978 [Pseudomonas allokribbensis]
ATGAGAACAATATTCTTTGAAACCACACTGTTCACCGCAAACCTGGGTCATTACCTCACGGACGACGAATATCGTGAGCT
ACAGACCTACATGCAGAGCAATCCGCATGCAGGCGATGTCATGCCACGAACCGGTGGCTTCCGAAAACTGCGTTGGGCGG
ATGCTCGTCGTGGTAAAGGCAGGAGAGGCGGCTTGCGAGTTATCTATTATTGGCTTATGAATGATGGCCAGTTTTGGATG
TTTGCGATTTATGACAAAGATGAGCTTGAGAATTTGACCGCCGATCAAGAGAGGGCGCTCAAGGGAGCCATAGAGAAAGA
GTTGAAAACACGAGGTACCCCATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145065 WP_000213183.1 NZ_CP046841:357996-358244 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145065 NZ_CP062252:c5400981-5400667 [Pseudomonas allokribbensis]
ATGAAAAAACGCGACCTGTTTGCAGAATTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATCACGCT
ACGTAATACGACACTTGAGGACAAACCAGCCCCCGAAGTCGCTGCTCAGGAAATCGTAGCGTTACGGGAAAAACTGCACA
TGTCACAGGCAGTTTTTGCCAGACGAATCAGGACAAGTCCAAGCACCCTCAGAAACTGGGAGCAGGAGAAATCAAAGCCC
AACGCTCAGGCTGCCTTGCTGATCCGTTTGGTGGAAAAATTCCCTGACATGGTCGAGCGACTGAGCGCTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References