Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426039..426586 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag J9265_RS16080 Protein ID WP_000229317.1
Coordinates 426284..426586 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag J9265_RS16075 Protein ID WP_000861987.1
Coordinates 426039..426296 (+) Length 86 a.a.

Genomic Context

J9265_RS16030J9265_RS19175J9265_RS16035J9265_RS19180J9265_RS19185J9265_RS16050J9265_RS16055J9265_RS16060J9265_RS19190J9265_RS16070J9265_RS19195J9265_RS16075J9265_RS16080J9265_RS16085J9265_RS16090J9265_RS16095J9265_RS16100J9265_RS16105J9265_RS16110J9265_RS16115J9265_RS16120J9265_RS16040J9265_RS16045
Location: 421068..421523 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421580..421702 (123 bp)
Type: Others
Protein ID: Protein_480
Location: 421873..421997 (125 bp)
Type: Others
Protein ID: Protein_481
Location: 422114..422182 (69 bp)
Type: Others
Protein ID: Protein_482
Location: 423117..423179 (63 bp)
Type: Others
Protein ID: Protein_485
Location: 423196..423864 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424016..424303 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424444..424815 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 425038..425307 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 425304..425837 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 425847..425957 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 426039..426296 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 426284..426586 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 426820..427737 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427894..428283 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428419..428628 (210 bp)
Type: Others
Protein ID: Protein_496
Location: 428747..429184 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429245..429466 (222 bp)
Type: Others
Protein ID: Protein_498
Location: 429641..430513 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430663..431262 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431319..431387 (69 bp)
Type: Others
Protein ID: Protein_501
Location: 422199..422696 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422693..422965 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J9265_RS16030 (J9265_16030)421068..421523+456WP_001245327.1GNAT family N-acetyltransferase-
J9265_RS19175421580..421702+123Protein_480acetyltransferase-
J9265_RS16035 (J9265_16035)421873..421997+125Protein_481DUF645 family protein-
J9265_RS19180422114..422182+69Protein_482acetyltransferase-
J9265_RS16040 (J9265_16040)422199..422696-498WP_000982260.1GNAT family N-acetyltransferase-
J9265_RS16045 (J9265_16045)422693..422965-273WP_000246253.1DUF1778 domain-containing protein-
J9265_RS19185423117..423179+63Protein_485acetyltransferase-
J9265_RS16050 (J9265_16050)423196..423864+669WP_000043871.1hypothetical protein-
J9265_RS16055 (J9265_16055)424016..424303+288WP_000426470.1hypothetical protein-
J9265_RS16060 (J9265_16060)424444..424815+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
J9265_RS19190425038..425307+270WP_000179600.1DUF1778 domain-containing protein-
J9265_RS16070 (J9265_16070)425304..425837+534WP_000118351.1GNAT family N-acetyltransferase-
J9265_RS19195425847..425957+111WP_086010065.1DUF3265 domain-containing protein-
J9265_RS16075 (J9265_16075)426039..426296+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
J9265_RS16080 (J9265_16080)426284..426586+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
J9265_RS16085 (J9265_16085)426820..427737+918WP_000186333.1alpha/beta hydrolase-
J9265_RS16090 (J9265_16090)427894..428283+390WP_001081302.1hypothetical protein-
J9265_RS16095 (J9265_16095)428419..428628+210Protein_496GNAT family N-acetyltransferase-
J9265_RS16100 (J9265_16100)428747..429184+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
J9265_RS16105 (J9265_16105)429245..429466+222Protein_498GNAT family N-acetyltransferase-
J9265_RS16110 (J9265_16110)429641..430513+873WP_000254716.1DUF3800 domain-containing protein-
J9265_RS16115 (J9265_16115)430663..431262+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
J9265_RS16120 (J9265_16120)431319..431387+69Protein_501acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805
flankIS/Tn--428747..429184437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T198992 WP_000229317.1 NZ_CP072848:426284-426586 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T198992 NZ_CP097082:1896528-1896630 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT198992 WP_000861987.1 NZ_CP072848:426039-426296 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT198992 NZ_CP097082:c1896637-1896492 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References