Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 369837..370452 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag A1552VC_RS16240 Protein ID WP_001162670.1
Coordinates 369837..370124 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A1552VC_RS16245 Protein ID WP_001232701.1
Coordinates 370135..370452 (+) Length 106 a.a.

Genomic Context

A1552VC_RS20120A1552VC_RS16210A1552VC_RS16215A1552VC_RS16220A1552VC_RS16225A1552VC_RS16230A1552VC_RS16240A1552VC_RS16245A1552VC_RS20125A1552VC_RS20045A1552VC_RS20050A1552VC_RS16270A1552VC_RS16275A1552VC_RS16280A1552VC_RS16290A1552VC_RS16295A1552VC_RS16200A1552VC_RS16205
Location: 365473..365568 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 366582..367091 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 367148..367801 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 368111..368329 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368732..368965 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 369390..369570 (181 bp)
Type: Others
Protein ID: Protein_362
Location: 369837..370124 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 370135..370452 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 370449..370559 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370736..370861 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370877..370915 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 371139..371879 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 372084..372914 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 372971..373453 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 373900..374775 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 374905..375360 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 365762..366079 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 366098..366340 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS20120365473..365568+96WP_001907607.1DUF645 family protein-
A1552VC_RS16200365762..366079-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
A1552VC_RS16205366098..366340-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A1552VC_RS16210366582..367091+510WP_000405987.1GNAT family N-acetyltransferase-
A1552VC_RS16215367148..367801+654WP_000226874.1hypothetical protein-
A1552VC_RS16220368111..368329+219WP_001917086.1DUF3709 domain-containing protein-
A1552VC_RS16225368732..368965+234WP_032482776.1DUF3709 domain-containing protein-
A1552VC_RS16230369390..369570+181Protein_362DUF645 family protein-
A1552VC_RS16240369837..370124+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A1552VC_RS16245370135..370452+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
A1552VC_RS20125370449..370559+111WP_134814058.1DUF3265 domain-containing protein-
A1552VC_RS20045370736..370861+126WP_001944767.1DUF645 family protein-
A1552VC_RS20050370877..370915+39WP_106019119.1hypothetical protein-
A1552VC_RS16270371139..371879+741WP_000469836.1PhzF family phenazine biosynthesis protein-
A1552VC_RS16275372084..372914+831WP_000056616.1abortive infection family protein-
A1552VC_RS16280372971..373453+483WP_001895003.1hypothetical protein-
A1552VC_RS16290373900..374775+876WP_000259044.1hypothetical protein-
A1552VC_RS16295374905..375360+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T104342 WP_001162670.1 NZ_CP028895:369837-370124 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T104342 NZ_CP028895:369837-370124 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT104342 WP_001232701.1 NZ_CP028895:370135-370452 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT104342 NZ_CP028895:370135-370452 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References