Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 445880..446973 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ81_RS16960 Protein ID WP_000351248.1
Coordinates 446572..446973 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ81_RS16955 Protein ID WP_001047169.1
Coordinates 445880..446572 (+) Length 231 a.a.

Genomic Context

ASZ81_RS16885ASZ81_RS20980ASZ81_RS16890ASZ81_RS16905ASZ81_RS16910ASZ81_RS16920ASZ81_RS16925ASZ81_RS16930ASZ81_RS20760ASZ81_RS16950ASZ81_RS16955ASZ81_RS16960ASZ81_RS20675ASZ81_RS16970ASZ81_RS16975ASZ81_RS16980ASZ81_RS16985ASZ81_RS16995ASZ81_RS17010ASZ81_RS17015ASZ81_RS16945ASZ81_RS17000ASZ81_RS17005
Location: 441163..441540 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 441597..441711 (115 bp)
Type: Others
Protein ID: Protein_485
Location: 441660..441941 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 442107..442220 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 442169..442396 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 442737..443069 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 443056..443370 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 443507..443941 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 444109..444264 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 445437..445743 (307 bp)
Type: Others
Protein ID: Protein_494
Location: 445880..446572 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 446572..446973 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 446943..447086 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 447161..447574 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 447788..448039 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 448029..448316 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 448444..448899 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 449221..449373 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 450572..451240 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 451392..451679 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 444389..445369 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 449575..450072 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 450069..450341 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS16885441163..441540+378WP_000411109.1hypothetical protein-
ASZ81_RS20980441597..441711+115Protein_485acetyltransferase-
ASZ81_RS16890441660..441941+282WP_001894453.1DUF1289 domain-containing protein-
ASZ81_RS16905442107..442220+114WP_001889158.1hypothetical protein-
ASZ81_RS16910442169..442396+228WP_001894457.1DUF1289 domain-containing protein-
ASZ81_RS16920442737..443069+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS16925443056..443370+315WP_000071008.1DNA-binding transcriptional regulator-
ASZ81_RS16930443507..443941+435WP_000256036.1GNAT family N-acetyltransferase-
ASZ81_RS20760444109..444264+156WP_000751734.1hypothetical protein-
ASZ81_RS16945444389..445369-981WP_000019370.1IS5-like element ISVch5 family transposase-
ASZ81_RS16950445437..445743+307Protein_494CatB-related O-acetyltransferase-
ASZ81_RS16955445880..446572+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
ASZ81_RS16960446572..446973+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
ASZ81_RS20675446943..447086+144WP_071908341.1DUF3265 domain-containing protein-
ASZ81_RS16970447161..447574+414WP_000049417.1VOC family protein-
ASZ81_RS16975447788..448039+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ81_RS16980448029..448316+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS16985448444..448899+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ81_RS16995449221..449373+153WP_001884520.1DUF645 family protein-
ASZ81_RS17000449575..450072-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ81_RS17005450069..450341-273WP_000246253.1DUF1778 domain-containing protein-
ASZ81_RS17010450572..451240+669WP_000043871.1hypothetical protein-
ASZ81_RS17015451392..451679+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353
flankIS/Tn--444389..445369980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58273 WP_000351248.1 NZ_CP013306:446572-446973 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58273 NZ_CP013306:446572-446973 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT58273 WP_001047169.1 NZ_CP013306:445880-446572 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58273 NZ_CP013306:445880-446572 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References