Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 413164..413797 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag VCA1552_RS16730 Protein ID WP_000843587.1
Coordinates 413164..413496 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VCA1552_RS16735 Protein ID WP_000071008.1
Coordinates 413483..413797 (+) Length 105 a.a.

Genomic Context

VCA1552_RS20030VCA1552_RS16660VCA1552_RS16665VCA1552_RS16675VCA1552_RS16680VCA1552_RS16685VCA1552_RS16690VCA1552_RS20035VCA1552_RS16695VCA1552_RS16710VCA1552_RS16715VCA1552_RS16730VCA1552_RS16735VCA1552_RS16740VCA1552_RS19910VCA1552_RS16750VCA1552_RS16755VCA1552_RS16760VCA1552_RS16765VCA1552_RS16770VCA1552_RS16775VCA1552_RS16780VCA1552_RS16745
Location: 408605..408808 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 409089..409262 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 409622..409891 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 410209..410380 (172 bp)
Type: Others
Protein ID: Protein_430
Location: 410589..410975 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 411177..411419 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 411590..411967 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 412024..412138 (115 bp)
Type: Others
Protein ID: Protein_434
Location: 412087..412368 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 412534..412647 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 412596..412823 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 413164..413496 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 413483..413797 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 413934..414368 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 414536..414691 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 415864..416136 (273 bp)
Type: Others
Protein ID: Protein_443
Location: 416307..416999 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 416999..417400 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 417370..417513 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 417588..418001 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 418215..418466 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 418456..418743 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 414816..415796 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS20030408605..408808+204WP_001911745.1hypothetical protein-
VCA1552_RS16660409089..409262+174WP_001882305.1DUF3709 domain-containing protein-
VCA1552_RS16665409622..409891+270WP_001198131.1hypothetical protein-
VCA1552_RS16675410209..410380+172Protein_430DUF645 family protein-
VCA1552_RS16680410589..410975+387WP_000703163.1VOC family protein-
VCA1552_RS16685411177..411419+243WP_000107461.1hypothetical protein-
VCA1552_RS16690411590..411967+378WP_000411109.1hypothetical protein-
VCA1552_RS20035412024..412138+115Protein_434acetyltransferase-
VCA1552_RS16695412087..412368+282WP_001894453.1DUF1289 domain-containing protein-
VCA1552_RS16710412534..412647+114WP_001889158.1hypothetical protein-
VCA1552_RS16715412596..412823+228WP_001894457.1DUF1289 domain-containing protein-
VCA1552_RS16730413164..413496+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCA1552_RS16735413483..413797+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
VCA1552_RS16740413934..414368+435WP_000256036.1GNAT family N-acetyltransferase-
VCA1552_RS19910414536..414691+156WP_000751734.1hypothetical protein-
VCA1552_RS16745414816..415796-981WP_000019370.1IS5-like element ISVch5 family transposase-
VCA1552_RS16750415864..416136+273Protein_443CatB-related O-acetyltransferase-
VCA1552_RS16755416307..416999+693WP_001047169.1GNAT family N-acetyltransferase-
VCA1552_RS16760416999..417400+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
VCA1552_RS16765417370..417513+144WP_071908341.1DUF3265 domain-containing protein-
VCA1552_RS16770417588..418001+414WP_000049417.1VOC family protein-
VCA1552_RS16775418215..418466+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCA1552_RS16780418456..418743+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--309797..433602123805
flankIS/Tn--414816..415796980
-insideGenomic islandcatB9-304717..433978129261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T88996 WP_000843587.1 NZ_CP024868:413164-413496 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T88996 NZ_CP024868:413164-413496 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT88996 WP_000071008.1 NZ_CP024868:413483-413797 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT88996 NZ_CP024868:413483-413797 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References