92510

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 396860..397388 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag C1H56_RS16525 Protein ID WP_000221352.1
Coordinates 396860..397150 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag C1H56_RS16530 Protein ID WP_000213183.1
Coordinates 397140..397388 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS19980 392417..392542 + 126 WP_001944767.1 DUF645 family protein -
C1H56_RS19985 392558..392596 + 39 WP_106019119.1 hypothetical protein -
C1H56_RS16495 392809..393813 + 1005 WP_000964925.1 LD-carboxypeptidase -
C1H56_RS16500 393966..394412 + 447 WP_000128977.1 hypothetical protein -
C1H56_RS16505 394532..395461 + 930 WP_000335802.1 hypothetical protein -
C1H56_RS16510 395458..395568 + 111 WP_071917832.1 DUF3265 domain-containing protein -
C1H56_RS16515 395596..396072 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
C1H56_RS16520 396209..396724 + 516 WP_001201528.1 lipocalin family protein -
C1H56_RS16525 396860..397150 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1H56_RS16530 397140..397388 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1H56_RS16545 397959..398612 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
C1H56_RS16550 398884..399309 + 426 WP_000415748.1 hypothetical protein -
C1H56_RS16555 399517..399912 + 396 WP_000649527.1 DUF3465 domain-containing protein -
C1H56_RS16560 400063..400593 + 531 WP_000415563.1 hypothetical protein -
C1H56_RS16565 400731..401231 + 501 WP_000789723.1 hypothetical protein -
C1H56_RS16575 401387..401785 + 399 WP_001882293.1 hypothetical protein -
C1H56_RS16580 401885..402349 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T92510 WP_000221352.1 NZ_CP025937:c397150-396860 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T92510 NZ_CP025937:c397150-396860 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT92510 WP_000213183.1 NZ_CP025937:c397388-397140 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT92510 NZ_CP025937:c397388-397140 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References