Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 334813..335311 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GTF72_RS15285 Protein ID WP_000589156.1
Coordinates 334813..335079 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GTF72_RS15290 Protein ID WP_000643598.1
Coordinates 335066..335311 (+) Length 82 a.a.

Genomic Context

GTF72_RS15230GTF72_RS15235GTF72_RS15240GTF72_RS15245GTF72_RS15250GTF72_RS15255GTF72_RS15260GTF72_RS15265GTF72_RS15270GTF72_RS15275GTF72_RS15280GTF72_RS15285GTF72_RS15290GTF72_RS15295GTF72_RS15300GTF72_RS15305GTF72_RS15310GTF72_RS15315GTF72_RS15320GTF72_RS15325GTF72_RS15330
Location: 330233..330439 (207 bp)
Type: Others
Protein ID: Protein_294
Location: 330639..330740 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330730..331116 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331311..331562 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331535..331684 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331776..332018 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332270..332548 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332923..333066 (144 bp)
Type: Others
Protein ID: Protein_301
Location: 333120..333158 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 333370..333837 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 333965..334628 (664 bp)
Type: Others
Protein ID: Protein_304
Location: 334813..335079 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 335066..335311 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 335407..336201 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 336304..336432 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 336493..336675 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 336891..337895 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 338048..338407 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 338680..338913 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 339181..339687 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 339844..340230 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15230330233..330439+207Protein_294DUF3709 domain-containing protein-
GTF72_RS15235330639..330740+102WP_001921603.1hypothetical protein-
GTF72_RS15240330730..331116+387WP_000703163.1VOC family protein-
GTF72_RS15245331311..331562+252WP_001890111.1TIGR03643 family protein-
GTF72_RS15250331535..331684+150WP_071908333.1DUF3265 domain-containing protein-
GTF72_RS15255331776..332018+243WP_000107461.1hypothetical protein-
GTF72_RS15260332270..332548+279WP_000280324.1DUF3709 domain-containing protein-
GTF72_RS15265332923..333066+144Protein_301DUF645 family protein-
GTF72_RS15270333120..333158+39WP_082798268.1hypothetical protein-
GTF72_RS15275333370..333837+468WP_001289288.1OsmC family protein-
GTF72_RS15280333965..334628+664Protein_304hypothetical protein-
GTF72_RS15285334813..335079+267WP_000589156.1BrnT family toxinToxin
GTF72_RS15290335066..335311+246WP_000643598.1hypothetical proteinAntitoxin
GTF72_RS15295335407..336201+795WP_001911581.1hypothetical protein-
GTF72_RS15300336304..336432+129WP_071908338.1general secretion pathway protein GspI-
GTF72_RS15305336493..336675+183WP_000923182.1DUF645 family protein-
GTF72_RS15310336891..337895+1005WP_000964920.1LD-carboxypeptidase-
GTF72_RS15315338048..338407+360WP_001071541.1VOC family protein-
GTF72_RS15320338680..338913+234WP_001890112.1DUF3709 domain-containing protein-
GTF72_RS15325339181..339687+507WP_000393074.1hypothetical protein-
GTF72_RS15330339844..340230+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145806 WP_000589156.1 NZ_CP047296:334813-335079 [Vibrio cholerae C6706]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145806 NZ_CP062700:c445546-445061 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145806 WP_000643598.1 NZ_CP047296:335066-335311 [Vibrio cholerae C6706]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145806 NZ_CP062700:c445815-445537 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References