104340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 350039..350577 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag A1552VC_RS16045 Protein ID WP_000802136.1
Coordinates 350039..350338 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag A1552VC_RS16050 Protein ID WP_001107719.1
Coordinates 350335..350577 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS15995 345974..346156 + 183 WP_000923182.1 DUF645 family protein -
A1552VC_RS16000 346356..346829 + 474 WP_001161076.1 GrpB family protein -
A1552VC_RS16005 346844..346936 + 93 WP_014378730.1 DUF3265 domain-containing protein -
A1552VC_RS16010 346978..347604 + 627 WP_000365424.1 LysE family translocator -
A1552VC_RS16015 347727..348425 + 699 WP_001890502.1 hypothetical protein -
A1552VC_RS16020 348435..348545 + 111 WP_079857360.1 DUF3265 domain-containing protein -
A1552VC_RS16035 349123..349302 + 180 WP_001883058.1 DUF645 family protein -
A1552VC_RS16040 349516..349911 + 396 WP_000870857.1 DUF3465 domain-containing protein -
A1552VC_RS16045 350039..350338 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1552VC_RS16050 350335..350577 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
A1552VC_RS16060 350806..351384 + 579 WP_000110120.1 hypothetical protein -
A1552VC_RS16065 351406..351498 + 93 WP_014164112.1 DUF3265 domain-containing protein -
A1552VC_RS16075 351922..352605 + 684 WP_000877436.1 hypothetical protein -
A1552VC_RS16085 352819..353085 + 267 WP_000937852.1 hypothetical protein -
A1552VC_RS16095 353240..353839 + 600 WP_000429495.1 hypothetical protein -
A1552VC_RS16100 354120..355055 + 936 WP_000051985.1 restriction endonuclease -
A1552VC_RS16105 355021..355161 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T104340 WP_000802136.1 NZ_CP028895:c350338-350039 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T104340 NZ_CP028895:c350338-350039 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT104340 WP_001107719.1 NZ_CP028895:c350577-350335 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT104340 NZ_CP028895:c350577-350335 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References