145869

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 349519..350057 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF75_RS15575 Protein ID WP_000802136.1
Coordinates 349519..349818 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF75_RS15580 Protein ID WP_001107719.1
Coordinates 349815..350057 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS15535 345454..345636 + 183 WP_000923182.1 DUF645 family protein -
GTF75_RS15540 345836..346309 + 474 WP_001161076.1 GrpB family protein -
GTF75_RS15545 346306..346416 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF75_RS15550 346458..347084 + 627 WP_000365424.1 LysE family translocator -
GTF75_RS15555 347207..347905 + 699 WP_001890502.1 hypothetical protein -
GTF75_RS15560 347909..348025 + 117 WP_071908339.1 DUF3265 domain-containing protein -
GTF75_RS15565 348603..348782 + 180 WP_001883058.1 DUF645 family protein -
GTF75_RS15570 348996..349391 + 396 WP_000870857.1 DUF3465 domain-containing protein -
GTF75_RS15575 349519..349818 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF75_RS15580 349815..350057 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GTF75_RS15585 350286..350864 + 579 WP_000110120.1 hypothetical protein -
GTF75_RS15590 350868..350978 + 111 WP_071908313.1 DUF3265 domain-containing protein -
GTF75_RS15595 351402..352085 + 684 WP_000877436.1 hypothetical protein -
GTF75_RS15600 352299..352565 + 267 WP_000937852.1 hypothetical protein -
GTF75_RS15605 352720..353319 + 600 WP_000429495.1 hypothetical protein -
GTF75_RS15610 353600..354535 + 936 WP_000051985.1 restriction endonuclease -
GTF75_RS15615 354501..354641 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145869 WP_000802136.1 NZ_CP047302:c349818-349519 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145869 NZ_CP062705:947785-948192 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145869 WP_001107719.1 NZ_CP047302:c350057-349815 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145869 NZ_CP062705:947538-947804 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References