Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 449575..450341 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ81_RS17000 Protein ID WP_000982260.1
Coordinates 449575..450072 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ81_RS17005 Protein ID WP_000246253.1
Coordinates 450069..450341 (-) Length 91 a.a.

Genomic Context

ASZ81_RS16950ASZ81_RS16955ASZ81_RS16960ASZ81_RS20675ASZ81_RS16970ASZ81_RS16975ASZ81_RS16980ASZ81_RS16985ASZ81_RS16995ASZ81_RS17010ASZ81_RS17015ASZ81_RS17020ASZ81_RS17025ASZ81_RS17030ASZ81_RS17035ASZ81_RS17040ASZ81_RS17045ASZ81_RS17000ASZ81_RS17005
Location: 445437..445743 (307 bp)
Type: Others
Protein ID: Protein_494
Location: 445880..446572 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 446572..446973 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 446943..447086 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 447161..447574 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 447788..448039 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 448029..448316 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 448444..448899 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 449221..449373 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 450572..451240 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 451392..451679 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 451820..452191 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 452258..452683 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 452680..453213 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 453415..453672 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 453660..453962 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 454196..455113 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 449575..450072 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 450069..450341 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS16950445437..445743+307Protein_494CatB-related O-acetyltransferase-
ASZ81_RS16955445880..446572+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ81_RS16960446572..446973+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ81_RS20675446943..447086+144WP_071908341.1DUF3265 domain-containing protein-
ASZ81_RS16970447161..447574+414WP_000049417.1VOC family protein-
ASZ81_RS16975447788..448039+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ81_RS16980448029..448316+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS16985448444..448899+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ81_RS16995449221..449373+153WP_001884520.1DUF645 family protein-
ASZ81_RS17000449575..450072-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ81_RS17005450069..450341-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ81_RS17010450572..451240+669WP_000043871.1hypothetical protein-
ASZ81_RS17015451392..451679+288WP_000426470.1hypothetical protein-
ASZ81_RS17020451820..452191+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ81_RS17025452258..452683+426WP_001882332.1DUF1778 domain-containing protein-
ASZ81_RS17030452680..453213+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ81_RS17035453415..453672+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ81_RS17040453660..453962+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS17045454196..455113+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353
flankIS/Tn--444389..445369980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58275 WP_000982260.1 NZ_CP013306:c450072-449575 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58275 NZ_CP013306:c450072-449575 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58275 WP_000246253.1 NZ_CP013306:c450341-450069 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58275 NZ_CP013306:c450341-450069 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References