38627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 98261..98789 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag K6J77_RS14655 Protein ID WP_000221354.1
Coordinates 98502..98789 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag K6J77_RS14650 Protein ID WP_001250179.1
Coordinates 98261..98512 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS14610 93529..93843 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
K6J77_RS14615 93980..94414 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
K6J77_RS14620 94582..94737 + 156 WP_000751734.1 hypothetical protein -
K6J77_RS14625 94862..95842 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K6J77_RS14630 95910..96216 + 307 Protein_179 CatB-related O-acetyltransferase -
K6J77_RS19080 96353..96751 + 399 Protein_180 GNAT family N-acetyltransferase -
K6J77_RS19085 96875..97045 + 171 WP_001080654.1 hypothetical protein -
K6J77_RS14640 97045..97446 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
K6J77_RS19090 97449..97559 + 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J77_RS14645 97634..98047 + 414 WP_000049417.1 VOC family protein -
K6J77_RS14650 98261..98512 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J77_RS14655 98502..98789 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J77_RS14660 98917..99372 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J77_RS19095 99429..99551 + 123 Protein_188 acetyltransferase -
K6J77_RS14665 99722..99846 + 125 Protein_189 DUF645 family protein -
K6J77_RS19100 99963..100031 + 69 Protein_190 acetyltransferase -
K6J77_RS14670 100048..100545 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J77_RS14675 100542..100814 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J77_RS19105 100966..101028 + 63 Protein_193 acetyltransferase -
K6J77_RS14680 101045..101713 + 669 WP_000043871.1 hypothetical protein -
K6J77_RS14685 101865..102152 + 288 WP_000426470.1 hypothetical protein -
K6J77_RS14690 102293..102664 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K6J77_RS19110 102887..103156 + 270 WP_000179600.1 DUF1778 domain-containing protein -
K6J77_RS14700 103153..103686 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670
flank IS/Tn - - 94862..95842 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T38627 WP_000221354.1 NZ_AP024548:98502-98789 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T38627 NZ_AP024548:98502-98789 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT38627 WP_001250179.1 NZ_AP024548:98261-98512 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT38627 NZ_AP024548:98261-98512 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References