Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 98261..98789 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag K6J77_RS14655 Protein ID WP_000221354.1
Coordinates 98502..98789 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag K6J77_RS14650 Protein ID WP_001250179.1
Coordinates 98261..98512 (+) Length 84 a.a.

Genomic Context

K6J77_RS14610K6J77_RS14615K6J77_RS14620K6J77_RS14630K6J77_RS19080K6J77_RS19085K6J77_RS14640K6J77_RS19090K6J77_RS14645K6J77_RS14650K6J77_RS14655K6J77_RS14660K6J77_RS19095K6J77_RS14665K6J77_RS19100K6J77_RS19105K6J77_RS14680K6J77_RS14685K6J77_RS14690K6J77_RS19110K6J77_RS14700K6J77_RS14625K6J77_RS14670K6J77_RS14675
Location: 93529..93843 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 93980..94414 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 94582..94737 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 95910..96216 (307 bp)
Type: Others
Protein ID: Protein_179
Location: 96353..96751 (399 bp)
Type: Others
Protein ID: Protein_180
Location: 96875..97045 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 97045..97446 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 97449..97559 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 97634..98047 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 98261..98512 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 98502..98789 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 98917..99372 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 99429..99551 (123 bp)
Type: Others
Protein ID: Protein_188
Location: 99722..99846 (125 bp)
Type: Others
Protein ID: Protein_189
Location: 99963..100031 (69 bp)
Type: Others
Protein ID: Protein_190
Location: 100966..101028 (63 bp)
Type: Others
Protein ID: Protein_193
Location: 101045..101713 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 101865..102152 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 102293..102664 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 102887..103156 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 103153..103686 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 94862..95842 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 100048..100545 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 100542..100814 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1461093529..93843+315WP_000071008.1DNA-binding transcriptional regulator-
K6J77_RS1461593980..94414+435WP_000256036.1GNAT family N-acetyltransferase-
K6J77_RS1462094582..94737+156WP_000751734.1hypothetical protein-
K6J77_RS1462594862..95842-981WP_000019370.1IS5-like element ISVch5 family transposase-
K6J77_RS1463095910..96216+307Protein_179CatB-related O-acetyltransferase-
K6J77_RS1908096353..96751+399Protein_180GNAT family N-acetyltransferase-
K6J77_RS1908596875..97045+171WP_001080654.1hypothetical protein-
K6J77_RS1464097045..97446+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
K6J77_RS1909097449..97559+111WP_082798255.1DUF3265 domain-containing protein-
K6J77_RS1464597634..98047+414WP_000049417.1VOC family protein-
K6J77_RS1465098261..98512+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K6J77_RS1465598502..98789+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J77_RS1466098917..99372+456WP_001245327.1GNAT family N-acetyltransferase-
K6J77_RS1909599429..99551+123Protein_188acetyltransferase-
K6J77_RS1466599722..99846+125Protein_189DUF645 family protein-
K6J77_RS1910099963..100031+69Protein_190acetyltransferase-
K6J77_RS14670100048..100545-498WP_000982260.1GNAT family N-acetyltransferase-
K6J77_RS14675100542..100814-273WP_000246253.1DUF1778 domain-containing protein-
K6J77_RS19105100966..101028+63Protein_193acetyltransferase-
K6J77_RS14680101045..101713+669WP_000043871.1hypothetical protein-
K6J77_RS14685101865..102152+288WP_000426470.1hypothetical protein-
K6J77_RS14690102293..102664+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K6J77_RS19110102887..103156+270WP_000179600.1DUF1778 domain-containing protein-
K6J77_RS14700103153..103686+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670
flankIS/Tn--94862..95842980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T38627 WP_000221354.1 NZ_AP024548:98502-98789 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T38627 NZ_AP024548:98502-98789 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT38627 WP_001250179.1 NZ_AP024548:98261-98512 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT38627 NZ_AP024548:98261-98512 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References