Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 58949..59447 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag C4E16_RS14530 Protein ID WP_000589156.1
Coordinates 58949..59215 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag C4E16_RS14535 Protein ID WP_000643598.1
Coordinates 59202..59447 (+) Length 82 a.a.

Genomic Context

C4E16_RS19420C4E16_RS14470C4E16_RS14475C4E16_RS14480C4E16_RS14485C4E16_RS14490C4E16_RS14495C4E16_RS19550C4E16_RS19555C4E16_RS14515C4E16_RS14520C4E16_RS14530C4E16_RS14535C4E16_RS14540C4E16_RS19560C4E16_RS14555C4E16_RS14560C4E16_RS14565C4E16_RS14570C4E16_RS14575C4E16_RS14580
Location: 54370..54576 (207 bp)
Type: Others
Protein ID: Protein_68
Location: 54776..54877 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 54867..55253 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 55448..55699 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 55672..55821 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 55913..56155 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 56407..56685 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 57060..57203 (144 bp)
Type: Others
Protein ID: Protein_75
Location: 57257..57295 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 57507..57974 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 58102..58764 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 58949..59215 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 59202..59447 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 59543..60337 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 60440..60568 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 60629..60811 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 61027..62031 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 62184..62543 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 62816..63049 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 63317..63823 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 63980..64366 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1942054370..54576+207Protein_68DUF3709 domain-containing protein-
C4E16_RS1447054776..54877+102WP_001921603.1hypothetical protein-
C4E16_RS1447554867..55253+387WP_000703163.1VOC family protein-
C4E16_RS1448055448..55699+252WP_001890111.1TIGR03643 family protein-
C4E16_RS1448555672..55821+150WP_071908333.1DUF3265 domain-containing protein-
C4E16_RS1449055913..56155+243WP_000107461.1hypothetical protein-
C4E16_RS1449556407..56685+279WP_000280324.1DUF3709 domain-containing protein-
C4E16_RS1955057060..57203+144Protein_75DUF645 family protein-
C4E16_RS1955557257..57295+39WP_082798268.1hypothetical protein-
C4E16_RS1451557507..57974+468WP_001289288.1OsmC family protein-
C4E16_RS1452058102..58764+663WP_000960654.1hypothetical protein-
C4E16_RS1453058949..59215+267WP_000589156.1BrnT family toxinToxin
C4E16_RS1453559202..59447+246WP_000643598.1hypothetical proteinAntitoxin
C4E16_RS1454059543..60337+795WP_001911581.1hypothetical protein-
C4E16_RS1956060440..60568+129WP_071908338.1general secretion pathway protein GspI-
C4E16_RS1455560629..60811+183WP_000923182.1DUF645 family protein-
C4E16_RS1456061027..62031+1005WP_000964920.1LD-carboxypeptidase-
C4E16_RS1456562184..62543+360WP_001071541.1VOC family protein-
C4E16_RS1457062816..63049+234WP_001890112.1DUF3709 domain-containing protein-
C4E16_RS1457563317..63823+507WP_000393074.1hypothetical protein-
C4E16_RS1458063980..64366+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T95378 WP_000589156.1 NZ_CP026648:58949-59215 [Vibrio cholerae O1 biovar El Tor]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T95378 NZ_CP026648:58949-59215 [Vibrio cholerae O1 biovar El Tor]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT95378 WP_000643598.1 NZ_CP026648:59202-59447 [Vibrio cholerae O1 biovar El Tor]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT95378 NZ_CP026648:59202-59447 [Vibrio cholerae O1 biovar El Tor]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References