Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 341897..342456 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag IR04_RS01600 Protein ID WP_000578476.1
Coordinates 341897..342175 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag IR04_RS01605 Protein ID WP_000381183.1
Coordinates 342172..342456 (-) Length 95 a.a.

Genomic Context

IR04_RS01560IR04_RS01565IR04_RS01570IR04_RS01575IR04_RS19225IR04_RS01580IR04_RS01585IR04_RS01590IR04_RS01595IR04_RS01610IR04_RS01615IR04_RS01620IR04_RS01625IR04_RS19240IR04_RS01630IR04_RS01635IR04_RS19245IR04_RS01600IR04_RS01605
Location: 336975..337481 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 337638..338024 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 338281..338484 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 338679..338930 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 338903..339052 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 339199..339624 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 339830..340453 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 340666..341145 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 341333..341746 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 342651..343166 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 343231..343827 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 344219..344401 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 344601..345074 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 345089..345181 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 345223..345849 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 345972..346670 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 346680..346790 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 341897..342175 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 342172..342456 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS01560336975..337481+507WP_000393074.1hypothetical protein-
IR04_RS01565337638..338024+387WP_000703163.1VOC family protein-
IR04_RS01570338281..338484+204WP_001911580.1hypothetical protein-
IR04_RS01575338679..338930+252WP_001890111.1TIGR03643 family protein-
IR04_RS19225338903..339052+150WP_071908333.1DUF3265 domain-containing protein-
IR04_RS01580339199..339624+426WP_000415750.1hypothetical protein-
IR04_RS01585339830..340453+624WP_000247070.1DUF1349 domain-containing protein-
IR04_RS01590340666..341145+480WP_000009888.1lecithin retinol acyltransferase family protein-
IR04_RS01595341333..341746+414WP_000049420.1VOC family protein-
IR04_RS01600341897..342175-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
IR04_RS01605342172..342456-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
IR04_RS01610342651..343166+516WP_001201520.1lipocalin family protein-
IR04_RS01615343231..343827+597WP_000255434.1hypothetical protein-
IR04_RS01620344219..344401+183WP_000923182.1DUF645 family protein-
IR04_RS01625344601..345074+474WP_001161076.1GrpB family protein-
IR04_RS19240345089..345181+93WP_014378730.1DUF3265 domain-containing protein-
IR04_RS01630345223..345849+627WP_000365424.1LysE family translocator-
IR04_RS01635345972..346670+699WP_001890502.1hypothetical protein-
IR04_RS19245346680..346790+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T48149 WP_000578476.1 NZ_CP009041:c342175-341897 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T48149 NZ_CP009041:c342175-341897 [Vibrio cholerae O1 biovar El Tor]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT48149 WP_000381183.1 NZ_CP009041:c342456-342172 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT48149 NZ_CP009041:c342456-342172 [Vibrio cholerae O1 biovar El Tor]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References