Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | dhiT-phd/- |
Location | 753539..753943 | Replicon | chromosome |
Accession | NZ_CP020407 | ||
Organism | Vibrio cholerae strain FDAARGOS_223 |
Toxin (Protein)
Gene name | dhiT | Uniprot ID | A0A086SLD6 |
Locus tag | A6J62_RS03395 | Protein ID | WP_001114075.1 |
Coordinates | 753539..753808 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | - |
Locus tag | A6J62_RS03400 | Protein ID | WP_099607150.1 |
Coordinates | 753839..753943 (-) | Length | 35 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A6J62_RS03350 | 749950..750363 | - | 414 | WP_000049420.1 | VOC family protein | - |
A6J62_RS03360 | 750547..751062 | - | 516 | WP_000343779.1 | GNAT family N-acetyltransferase | - |
A6J62_RS03365 | 751256..751540 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
A6J62_RS03370 | 751537..751815 | + | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
A6J62_RS03375 | 751954..752349 | - | 396 | WP_001000867.1 | hypothetical protein | - |
A6J62_RS03385 | 752600..752725 | - | 126 | WP_001905700.1 | DUF645 family protein | - |
A6J62_RS03390 | 753024..753545 | - | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
A6J62_RS03395 | 753539..753808 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
A6J62_RS03400 | 753839..753943 | - | 105 | WP_099607150.1 | acetyltransferase | Antitoxin |
A6J62_RS03405 | 754000..754599 | - | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
A6J62_RS03410 | 754749..755621 | - | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
A6J62_RS03415 | 755796..756014 | - | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
A6J62_RS03420 | 756078..756515 | - | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
A6J62_RS03425 | 756634..756843 | - | 210 | Protein_647 | GNAT family N-acetyltransferase | - |
A6J62_RS03430 | 756979..757368 | - | 390 | WP_001081302.1 | hypothetical protein | - |
A6J62_RS03435 | 757525..758442 | - | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 749087..881909 | 132822 | |
inside | Integron | - | - | 749463..875103 | 125640 | ||
flank | IS/Tn | - | - | 756078..756515 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T74616 WP_001114075.1 NZ_CP020407:c753808-753539 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T74616 NZ_CP020407:c753808-753539 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
Antitoxin
Download Length: 35 a.a. Molecular weight: 3991.79 Da Isoelectric Point: 9.2853
>AT74616 WP_099607150.1 NZ_CP020407:c753943-753839 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
Download Length: 105 bp
>AT74616 NZ_CP020407:c753943-753839 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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