23794

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1035066..1035832 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCD_RS19505 Protein ID WP_000982260.1
Coordinates 1035335..1035832 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VCD_RS19500 Protein ID WP_000246253.1
Coordinates 1035066..1035338 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS19460 1030563..1030805 - 243 WP_000107461.1 hypothetical protein -
VCD_RS20550 1030897..1031046 - 150 WP_071908333.1 DUF3265 domain-containing protein -
VCD_RS19465 1031019..1031270 - 252 WP_001890111.1 TIGR03643 family protein -
VCD_RS19470 1031465..1031851 - 387 WP_000703163.1 VOC family protein -
VCD_RS20935 1031841..1031942 - 102 WP_001921603.1 hypothetical protein -
VCD_RS20940 1032142..1032348 - 207 Protein_963 DUF3709 domain-containing protein -
VCD_RS20560 1032600..1032878 - 279 WP_001921601.1 DUF3709 domain-containing protein -
VCD_RS19480 1033164..1033442 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
VCD_RS19485 1033435..1033704 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
VCD_RS19490 1033852..1034298 - 447 WP_000006157.1 hypothetical protein -
VCD_RS20945 1034494..1034532 - 39 WP_106019118.1 hypothetical protein -
VCD_RS20795 1034548..1034673 - 126 WP_001900195.1 DUF645 family protein -
VCD_RS19500 1035066..1035338 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
VCD_RS19505 1035335..1035832 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
VCD_RS19510 1035982..1036497 - 516 WP_001201509.1 lipocalin family protein -
VCD_RS19515 1036634..1037170 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
VCD_RS19525 1037428..1037709 - 282 WP_001894429.1 DUF1289 domain-containing protein -
VCD_RS20575 1037658..1037771 - 114 WP_001900214.1 hypothetical protein -
VCD_RS19530 1037828..1038214 - 387 WP_001015867.1 NUDIX hydrolase -
VCD_RS19535 1038458..1038700 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCD_RS19540 1038719..1039036 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCD_RS19545 1039190..1039528 - 339 WP_000713853.1 hypothetical protein -
VCD_RS19550 1039686..1040390 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T23794 WP_000982260.1 NC_012667:1035335-1035832 [Vibrio cholerae MJ-1236]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T23794 NC_012667:1035335-1035832 [Vibrio cholerae MJ-1236]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT23794 WP_000246253.1 NC_012667:1035066-1035338 [Vibrio cholerae MJ-1236]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT23794 NC_012667:1035066-1035338 [Vibrio cholerae MJ-1236]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References