145827

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343639..344198 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF73_RS15395 Protein ID WP_000578476.1
Coordinates 343639..343917 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF73_RS15400 Protein ID WP_000381183.1
Coordinates 343914..344198 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15345 338676..338909 + 234 WP_001890112.1 DUF3709 domain-containing protein -
GTF73_RS15350 339177..339683 + 507 WP_000393074.1 hypothetical protein -
GTF73_RS15355 339840..340226 + 387 WP_000703163.1 VOC family protein -
GTF73_RS15360 340421..340672 + 252 WP_001890111.1 TIGR03643 family protein -
GTF73_RS15365 340645..340794 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF73_RS15370 340941..341366 + 426 WP_000415750.1 hypothetical protein -
GTF73_RS15375 341572..342195 + 624 WP_000247070.1 DUF1349 domain-containing protein -
GTF73_RS15380 342408..342887 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
GTF73_RS15385 343075..343488 + 414 WP_000049420.1 VOC family protein -
GTF73_RS15390 343495..343590 - 96 Protein_321 hypothetical protein -
GTF73_RS15395 343639..343917 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GTF73_RS15400 343914..344198 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF73_RS15405 344393..344908 + 516 WP_001201520.1 lipocalin family protein -
GTF73_RS15410 344973..345569 + 597 WP_000255434.1 hypothetical protein -
GTF73_RS15415 345961..346143 + 183 WP_000923182.1 DUF645 family protein -
GTF73_RS15420 346343..346816 + 474 WP_001161076.1 GrpB family protein -
GTF73_RS15425 346813..346923 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF73_RS15430 346965..347591 + 627 WP_000365424.1 LysE family translocator -
GTF73_RS15435 347714..348412 + 699 WP_001890502.1 hypothetical protein -
GTF73_RS15440 348416..348532 + 117 WP_071908339.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145827 WP_000578476.1 NZ_CP047298:c343917-343639 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145827 NZ_CP062700:c5033727-5033554 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145827 WP_000381183.1 NZ_CP047298:c344198-343914 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145827 NZ_CP062700:c5034051-5033755 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References