Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 133506..134065 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag C4E16_RS15315 Protein ID WP_000578476.1
Coordinates 133506..133784 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag C4E16_RS15320 Protein ID WP_000381183.1
Coordinates 133781..134065 (-) Length 95 a.a.

Genomic Context

C4E16_RS15265C4E16_RS15270C4E16_RS15275C4E16_RS15280C4E16_RS15285C4E16_RS15290C4E16_RS15295C4E16_RS15300C4E16_RS15310C4E16_RS15325C4E16_RS15335C4E16_RS15345C4E16_RS15315C4E16_RS15320
Location: 128806..129243 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 129307..129525 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 129700..130572 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 130722..131321 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 131378..131482 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 131513..131782 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 131776..132297 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 132596..132721 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 132972..133367 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 134259..134774 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 134958..135371 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 135926..137103 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 133506..133784 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 133781..134065 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS15265128806..129243+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
C4E16_RS15270129307..129525+219WP_071908318.1GNAT family N-acetyltransferase-
C4E16_RS15275129700..130572+873WP_000254716.1DUF3800 domain-containing protein-
C4E16_RS15280130722..131321+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
C4E16_RS15285131378..131482+105WP_099607150.1acetyltransferase-
C4E16_RS15290131513..131782+270WP_001114075.1DUF4160 domain-containing protein-
C4E16_RS15295131776..132297+522WP_000921691.1DUF2442 domain-containing protein-
C4E16_RS15300132596..132721+126WP_001905700.1DUF645 family protein-
C4E16_RS15310132972..133367+396WP_001000867.1hypothetical protein-
C4E16_RS15315133506..133784-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
C4E16_RS15320133781..134065-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
C4E16_RS15325134259..134774+516WP_000343779.1GNAT family N-acetyltransferase-
C4E16_RS15335134958..135371+414WP_000049420.1VOC family protein-
C4E16_RS15345135926..137103+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735
flankIS/Tn--128806..129243437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T95392 WP_000578476.1 NZ_CP026648:c133784-133506 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T95392 NZ_CP026648:c133784-133506 [Vibrio cholerae O1 biovar El Tor]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT95392 WP_000381183.1 NZ_CP026648:c134065-133781 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT95392 NZ_CP026648:c134065-133781 [Vibrio cholerae O1 biovar El Tor]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References