Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE-RelB |
Location | 376769..377328 | Replicon | chromosome |
Accession | NZ_CP013314 | ||
Organism | Vibrio cholerae strain E9120 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q9K2M8 |
Locus tag | ASZ79_RS16145 | Protein ID | WP_000578476.1 |
Coordinates | 376769..377047 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9L991 |
Locus tag | ASZ79_RS16150 | Protein ID | WP_000381183.1 |
Coordinates | 377044..377328 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ79_RS16100 | 371847..372353 | + | 507 | WP_000393074.1 | hypothetical protein | - |
ASZ79_RS16105 | 372510..372896 | + | 387 | WP_000703163.1 | VOC family protein | - |
ASZ79_RS16110 | 373153..373356 | + | 204 | WP_001911580.1 | hypothetical protein | - |
ASZ79_RS16115 | 373551..373802 | + | 252 | WP_001890111.1 | TIGR03643 family protein | - |
ASZ79_RS16120 | 373775..373924 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
ASZ79_RS16125 | 374071..374496 | + | 426 | WP_000415750.1 | hypothetical protein | - |
ASZ79_RS16130 | 374702..375325 | + | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
ASZ79_RS16135 | 375538..376017 | + | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
ASZ79_RS16140 | 376205..376618 | + | 414 | WP_000049420.1 | VOC family protein | - |
ASZ79_RS16145 | 376769..377047 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
ASZ79_RS16150 | 377044..377328 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
ASZ79_RS16160 | 377523..378038 | + | 516 | WP_001201520.1 | lipocalin family protein | - |
ASZ79_RS16165 | 378103..378699 | + | 597 | WP_000255434.1 | hypothetical protein | - |
ASZ79_RS16180 | 379091..379273 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
ASZ79_RS16185 | 379473..379946 | + | 474 | WP_001161076.1 | GrpB family protein | - |
ASZ79_RS16190 | 379961..380053 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
ASZ79_RS16195 | 380095..380721 | + | 627 | WP_000365424.1 | LysE family translocator | - |
ASZ79_RS16210 | 381412..381591 | + | 180 | WP_001883058.1 | DUF645 family protein | - |
ASZ79_RS16215 | 381805..382200 | + | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 304700..468464 | 163764 | |
inside | Integron | - | - | 309780..468088 | 158308 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T58357 WP_000578476.1 NZ_CP013314:c377047-376769 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T58357 NZ_CP013314:c377047-376769 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT58357 WP_000381183.1 NZ_CP013314:c377328-377044 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT58357 NZ_CP013314:c377328-377044 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9K2M8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A067BL33 |