Detailed information of TA system TA045804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 327929..328469
• Replicon: chromosome
• Accession: NZ_CP006948
• Organism: Vibrio cholerae O1 str. KW3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A151JGK8
• Locus tag: N900_RS15510
• Protein ID: WP_000277238.1
• Coordinates: 327929..328198 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KML3
• Locus tag: N900_RS15515
• Protein ID: WP_001258569.1
• Coordinates: 328191..328469 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N900_RS15475	323150..323686	+	537	WP_000469482.1	GNAT family N-acetyltransferase	-
N900_RS15480	323823..324338	+	516	WP_001201509.1	lipocalin family protein	-
N900_RS15485	324488..324985	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
N900_RS15490	324982..325254	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
N900_RS19910	325647..325772	+	126	WP_001900195.1	DUF645 family protein	-
N900_RS19915	325788..325826	+	39	WP_106019118.1	hypothetical protein	-
N900_RS15500	326022..326468	+	447	WP_000006157.1	hypothetical protein	-
N900_RS15505	326531..327742	+	1212	WP_001122813.1	IS256 family transposase	-
N900_RS15510	327929..328198	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	Toxin
N900_RS15515	328191..328469	-	279	WP_001258569.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
N900_RS19435	328755..329033	+	279	WP_001921601.1	DUF3709 domain-containing protein	-
N900_RS19930	329285..329491	+	207	Protein_291	DUF3709 domain-containing protein	-
N900_RS19935	329691..329792	+	102	WP_001921603.1	hypothetical protein	-
N900_RS15525	329782..330168	+	387	WP_000703163.1	VOC family protein	-
N900_RS15530	330363..330614	+	252	WP_001890111.1	TIGR03643 family protein	-
N900_RS19445	330587..330736	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
N900_RS15535	330828..331070	+	243	WP_000107461.1	hypothetical protein	-
N900_RS19450	331214..331599	+	386	Protein_297	DUF3709 domain-containing protein	-
N900_RS20340	331974..332117	+	144	Protein_298	DUF645 family protein	-
N900_RS20345	332171..332209	+	39	WP_082798268.1	hypothetical protein	-
N900_RS15545	332421..332888	+	468	WP_001289288.1	OsmC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304645..411088	106443
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	309725..410760	101035
	-	flank	IS/Tn	-	-	326531..327742	1211

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10406.11 Da
• Isoelectric Point: 9.5084

>T45804 WP_000277238.1 NZ_CP006948:c328198-327929 [Vibrio cholerae O1 str. KW3]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T45804 NZ_CP006948:c328198-327929 [Vibrio cholerae O1 str. KW3]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10088.58 Da
• Isoelectric Point: 6.0728

>AT45804 WP_001258569.1 NZ_CP006948:c328469-328191 [Vibrio cholerae O1 str. KW3]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Nucleotide

• Length: 279 bp

>AT45804 NZ_CP006948:c328469-328191 [Vibrio cholerae O1 str. KW3]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Structures

Toxin

• AlphaFold DB: A0A151JGK8

Antitoxin

• AlphaFold DB: A0A151KTP9