Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 815636..816420 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag NW313_RS17970 Protein ID WP_001114075.1
Coordinates 815636..815905 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag NW313_RS17975 Protein ID WP_000921691.1
Coordinates 815899..816420 (+) Length 174 a.a.

Genomic Context

NW313_RS17930NW313_RS17935NW313_RS17940NW313_RS17945NW313_RS17950NW313_RS17955NW313_RS17960NW313_RS17965NW313_RS17970NW313_RS17975NW313_RS17980NW313_RS17985NW313_RS18000NW313_RS18005NW313_RS18010NW313_RS17990NW313_RS17995
Location: 811002..811919 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 812076..812465 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 812601..812810 (210 bp)
Type: Others
Protein ID: Protein_811
Location: 812929..813366 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 813427..813648 (222 bp)
Type: Others
Protein ID: Protein_813
Location: 813823..814695 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 814845..815444 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 815501..815569 (69 bp)
Type: Others
Protein ID: Protein_816
Location: 815636..815905 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 815899..816420 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 816719..816844 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 817095..817490 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 818382..818897 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 819081..819494 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 820049..821226 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 817629..817907 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 817904..818188 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW313_RS17930811002..811919+918WP_000186333.1alpha/beta hydrolase-
NW313_RS17935812076..812465+390WP_001081302.1hypothetical protein-
NW313_RS17940812601..812810+210Protein_811GNAT family N-acetyltransferase-
NW313_RS17945812929..813366+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
NW313_RS17950813427..813648+222Protein_813GNAT family N-acetyltransferase-
NW313_RS17955813823..814695+873WP_000254716.1DUF3800 domain-containing protein-
NW313_RS17960814845..815444+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
NW313_RS17965815501..815569+69Protein_816acetyltransferase-
NW313_RS17970815636..815905+270WP_001114075.1DUF4160 domain-containing proteinToxin
NW313_RS17975815899..816420+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
NW313_RS17980816719..816844+126WP_001905700.1DUF645 family protein-
NW313_RS17985817095..817490+396WP_001000867.1hypothetical protein-
NW313_RS17990817629..817907-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
NW313_RS17995817904..818188-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
NW313_RS18000818382..818897+516WP_000343779.1GNAT family protein-
NW313_RS18005819081..819494+414WP_000049420.1VOC family protein-
NW313_RS18010820049..821226+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-713852..820357106505
insideIntegroncatB9-718932..819981101049
flankIS/Tn--812929..813366437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T254480 WP_001114075.1 NZ_CP102928:815636-815905 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T254480 NZ_CP102928:815636-815905 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT254480 WP_000921691.1 NZ_CP102928:815899-816420 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT254480 NZ_CP102928:815899-816420 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References