Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 450793..451886 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ79_RS16900 Protein ID WP_000351248.1
Coordinates 451485..451886 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ79_RS16895 Protein ID WP_001047169.1
Coordinates 450793..451485 (+) Length 231 a.a.

Genomic Context

ASZ79_RS16825ASZ79_RS21050ASZ79_RS16830ASZ79_RS16845ASZ79_RS16850ASZ79_RS16860ASZ79_RS16865ASZ79_RS16870ASZ79_RS20835ASZ79_RS16890ASZ79_RS16895ASZ79_RS16900ASZ79_RS20750ASZ79_RS16910ASZ79_RS16915ASZ79_RS16920ASZ79_RS16925ASZ79_RS16935ASZ79_RS16950ASZ79_RS16955ASZ79_RS16885ASZ79_RS16940ASZ79_RS16945
Location: 446076..446453 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 446510..446624 (115 bp)
Type: Others
Protein ID: Protein_490
Location: 446573..446854 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 447020..447133 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 447082..447309 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 447650..447982 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 447969..448283 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 448420..448854 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 449022..449177 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 450350..450656 (307 bp)
Type: Others
Protein ID: Protein_499
Location: 450793..451485 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 451485..451886 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 451856..451999 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 452074..452487 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 452701..452952 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 452942..453229 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 453357..453812 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 454134..454286 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 455485..456153 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 456305..456592 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 449302..450282 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 454488..454985 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 454982..455254 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS16825446076..446453+378WP_000411109.1hypothetical protein-
ASZ79_RS21050446510..446624+115Protein_490acetyltransferase-
ASZ79_RS16830446573..446854+282WP_001894453.1DUF1289 domain-containing protein-
ASZ79_RS16845447020..447133+114WP_001889158.1hypothetical protein-
ASZ79_RS16850447082..447309+228WP_001894457.1DUF1289 domain-containing protein-
ASZ79_RS16860447650..447982+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS16865447969..448283+315WP_000071008.1DNA-binding transcriptional regulator-
ASZ79_RS16870448420..448854+435WP_000256036.1GNAT family N-acetyltransferase-
ASZ79_RS20835449022..449177+156WP_000751734.1hypothetical protein-
ASZ79_RS16885449302..450282-981WP_000019370.1IS5-like element ISVch5 family transposase-
ASZ79_RS16890450350..450656+307Protein_499CatB-related O-acetyltransferase-
ASZ79_RS16895450793..451485+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
ASZ79_RS16900451485..451886+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
ASZ79_RS20750451856..451999+144WP_071908341.1DUF3265 domain-containing protein-
ASZ79_RS16910452074..452487+414WP_000049417.1VOC family protein-
ASZ79_RS16915452701..452952+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ79_RS16920452942..453229+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS16925453357..453812+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ79_RS16935454134..454286+153WP_001884520.1DUF645 family protein-
ASZ79_RS16940454488..454985-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ79_RS16945454982..455254-273WP_000246253.1DUF1778 domain-containing protein-
ASZ79_RS16950455485..456153+669WP_000043871.1hypothetical protein-
ASZ79_RS16955456305..456592+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308
flankIS/Tn--449302..450282980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58363 WP_000351248.1 NZ_CP013314:451485-451886 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58363 NZ_CP013314:451485-451886 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT58363 WP_001047169.1 NZ_CP013314:450793-451485 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58363 NZ_CP013314:450793-451485 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References