180867

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 395176..395716 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag IT766_RS15465 Protein ID WP_000277238.1
Coordinates 395176..395445 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag IT766_RS15470 Protein ID WP_001258569.1
Coordinates 395438..395716 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS15410 390180..390422 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IT766_RS15415 390666..391052 + 387 WP_001015867.1 NUDIX hydrolase -
IT766_RS15420 391109..391222 + 114 WP_001900214.1 hypothetical protein -
IT766_RS15425 391171..391452 + 282 WP_001894429.1 DUF1289 domain-containing protein -
IT766_RS15430 391710..392246 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
IT766_RS15435 392383..392898 + 516 WP_001201509.1 lipocalin family protein -
IT766_RS15440 393048..393545 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
IT766_RS15445 393542..393814 - 273 WP_000246253.1 DUF1778 domain-containing protein -
IT766_RS15450 394207..394332 + 126 WP_001900195.1 DUF645 family protein -
IT766_RS15455 394348..394386 + 39 WP_106019118.1 hypothetical protein -
IT766_RS15460 394582..395028 + 447 WP_000006157.1 hypothetical protein -
IT766_RS15465 395176..395445 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
IT766_RS15470 395438..395716 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IT766_RS15475 396002..396280 + 279 WP_001921601.1 DUF3709 domain-containing protein -
IT766_RS15480 396532..396738 + 207 Protein_346 DUF3709 domain-containing protein -
IT766_RS15485 396938..397039 + 102 WP_001921603.1 hypothetical protein -
IT766_RS15490 397029..397415 + 387 WP_000703163.1 VOC family protein -
IT766_RS15495 397610..397861 + 252 WP_001890111.1 TIGR03643 family protein -
IT766_RS15500 397834..397983 + 150 WP_071908333.1 DUF3265 domain-containing protein -
IT766_RS15505 398075..398317 + 243 WP_000107461.1 hypothetical protein -
IT766_RS15510 398569..398847 + 279 WP_000280324.1 DUF3709 domain-containing protein -
IT766_RS15515 399222..399365 + 144 Protein_353 DUF645 family protein -
IT766_RS15520 399419..399457 + 39 WP_082798268.1 hypothetical protein -
IT766_RS15525 399669..400136 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T180867 WP_000277238.1 NZ_CP064351:c395445-395176 [Vibrio cholerae C6706]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T180867 NZ_CP085767:c1017897-1017487 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT180867 WP_001258569.1 NZ_CP064351:c395716-395438 [Vibrio cholerae C6706]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT180867 NZ_CP085767:c1018144-1017878 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References