Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 170182..170797 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag ASZ83_RS15125 Protein ID WP_001162670.1
Coordinates 170182..170469 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ83_RS15130 Protein ID WP_001232701.1
Coordinates 170480..170797 (+) Length 106 a.a.

Genomic Context

ASZ83_RS20455ASZ83_RS15095ASZ83_RS15100ASZ83_RS15105ASZ83_RS15115ASZ83_RS15120ASZ83_RS15125ASZ83_RS15130ASZ83_RS20460ASZ83_RS20465ASZ83_RS20470ASZ83_RS15150ASZ83_RS15155ASZ83_RS15160ASZ83_RS15170ASZ83_RS15175ASZ83_RS15085ASZ83_RS15090
Location: 165818..165913 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 166927..167436 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 167493..168146 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 168456..168674 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 169077..169310 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 169735..169915 (181 bp)
Type: Others
Protein ID: Protein_218
Location: 170182..170469 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 170480..170797 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 170794..170904 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 171081..171206 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 171222..171260 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 171484..172224 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 172429..173259 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 173316..173798 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 174245..175120 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 175250..175705 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 166107..166424 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 166443..166685 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS20455165818..165913+96WP_001907607.1DUF645 family protein-
ASZ83_RS15085166107..166424-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS15090166443..166685-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ83_RS15095166927..167436+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ83_RS15100167493..168146+654WP_000226874.1hypothetical protein-
ASZ83_RS15105168456..168674+219WP_001917086.1DUF3709 domain-containing protein-
ASZ83_RS15115169077..169310+234WP_032482776.1DUF3709 domain-containing protein-
ASZ83_RS15120169735..169915+181Protein_218DUF645 family protein-
ASZ83_RS15125170182..170469+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ83_RS15130170480..170797+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
ASZ83_RS20460170794..170904+111WP_134814058.1DUF3265 domain-containing protein-
ASZ83_RS20465171081..171206+126WP_001944767.1DUF645 family protein-
ASZ83_RS20470171222..171260+39WP_106019119.1hypothetical protein-
ASZ83_RS15150171484..172224+741WP_000469836.1PhzF family phenazine biosynthesis protein-
ASZ83_RS15155172429..173259+831WP_000056616.1abortive infection family protein-
ASZ83_RS15160173316..173798+483WP_001895003.1hypothetical protein-
ASZ83_RS15170174245..175120+876WP_000259044.1hypothetical protein-
ASZ83_RS15175175250..175705+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T58381 WP_001162670.1 NZ_CP013316:170182-170469 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T58381 NZ_CP013316:170182-170469 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT58381 WP_001232701.1 NZ_CP013316:170480-170797 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT58381 NZ_CP013316:170480-170797 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References