Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 217249..218033 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ83_RS15595 Protein ID WP_001114075.1
Coordinates 217249..217518 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag ASZ83_RS15600 Protein ID WP_000921691.1
Coordinates 217512..218033 (+) Length 174 a.a.

Genomic Context

ASZ83_RS15550ASZ83_RS15560ASZ83_RS15565ASZ83_RS15570ASZ83_RS15575ASZ83_RS15585ASZ83_RS15590ASZ83_RS20230ASZ83_RS15595ASZ83_RS15600ASZ83_RS20235ASZ83_RS15615ASZ83_RS15630ASZ83_RS15635ASZ83_RS15650ASZ83_RS15620ASZ83_RS15625
Location: 212615..213532 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 213689..214078 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 214214..214423 (210 bp)
Type: Others
Protein ID: Protein_296
Location: 214542..214979 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 215043..215261 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 215436..216308 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 216458..217057 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 217114..217218 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 217249..217518 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 217512..218033 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 218332..218457 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 218708..219103 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 219995..220510 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 220694..221107 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 221662..222839 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 219242..219520 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 219517..219801 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS15550212615..213532+918WP_000186333.1alpha/beta hydrolase-
ASZ83_RS15560213689..214078+390WP_001081302.1hypothetical protein-
ASZ83_RS15565214214..214423+210Protein_296GNAT family N-acetyltransferase-
ASZ83_RS15570214542..214979+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ83_RS15575215043..215261+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ83_RS15585215436..216308+873WP_000254716.1DUF3800 domain-containing protein-
ASZ83_RS15590216458..217057+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ83_RS20230217114..217218+105WP_099607150.1acetyltransferase-
ASZ83_RS15595217249..217518+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ83_RS15600217512..218033+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
ASZ83_RS20235218332..218457+126WP_001905700.1DUF645 family protein-
ASZ83_RS15615218708..219103+396WP_001000867.1hypothetical protein-
ASZ83_RS15620219242..219520-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ83_RS15625219517..219801-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ83_RS15630219995..220510+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ83_RS15635220694..221107+414WP_000049420.1VOC family protein-
ASZ83_RS15650221662..222839+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533
flankIS/Tn--214542..214979437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58388 WP_001114075.1 NZ_CP013316:217249-217518 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58388 NZ_CP013316:217249-217518 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT58388 WP_000921691.1 NZ_CP013316:217512-218033 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58388 NZ_CP013316:217512-218033 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References