199000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328900..329440 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag KAF59_RS15295 Protein ID WP_000277238.1
Coordinates 328900..329169 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag KAF59_RS15300 Protein ID WP_001258569.1
Coordinates 329162..329440 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15240 (KAF59_15240) 323904..324146 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15245 (KAF59_15245) 324390..324776 + 387 WP_001015867.1 NUDIX hydrolase -
KAF59_RS15250 (KAF59_15250) 324833..324946 + 114 WP_001900214.1 hypothetical protein -
KAF59_RS15255 (KAF59_15255) 324955..325176 + 222 WP_032467793.1 DUF1289 domain-containing protein -
KAF59_RS15260 (KAF59_15260) 325434..325970 + 537 WP_000469482.1 GNAT family protein -
KAF59_RS15265 (KAF59_15265) 326161..326622 + 462 WP_001903091.1 lipocalin family protein -
KAF59_RS18800 326687..326755 + 69 Protein_286 acetyltransferase -
KAF59_RS15270 (KAF59_15270) 326772..327269 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
KAF59_RS15275 (KAF59_15275) 327266..327538 - 273 WP_000246253.1 DUF1778 domain-containing protein -
KAF59_RS15280 (KAF59_15280) 327931..328056 + 126 WP_001900195.1 DUF645 family protein -
KAF59_RS15290 (KAF59_15290) 328306..328752 + 447 WP_000006157.1 hypothetical protein -
KAF59_RS15295 (KAF59_15295) 328900..329169 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
KAF59_RS15300 (KAF59_15300) 329162..329440 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KAF59_RS18805 329491..329608 + 118 Protein_293 DUF3265 domain-containing protein -
KAF59_RS15305 (KAF59_15305) 329726..330004 + 279 WP_001921601.1 DUF3709 domain-containing protein -
KAF59_RS18810 330364..330462 + 99 WP_223225486.1 DUF3709 domain-containing protein -
KAF59_RS15315 (KAF59_15315) 330662..330763 + 102 WP_001921603.1 hypothetical protein -
KAF59_RS15320 (KAF59_15320) 330753..331139 + 387 WP_000703163.1 VOC family protein -
KAF59_RS15325 (KAF59_15325) 331334..331585 + 252 WP_001890111.1 TIGR03643 family protein -
KAF59_RS15330 (KAF59_15330) 331558..331707 + 150 WP_071908333.1 DUF3265 domain-containing protein -
KAF59_RS15335 (KAF59_15335) 331799..332041 + 243 WP_000107461.1 hypothetical protein -
KAF59_RS15340 (KAF59_15340) 332293..332571 + 279 WP_000280324.1 DUF3709 domain-containing protein -
KAF59_RS18815 333003..333046 + 44 Protein_302 hypothetical protein -
KAF59_RS18820 333028..333121 + 94 Protein_303 ggdef family protein -
KAF59_RS18825 333090..333221 + 132 WP_001883067.1 hypothetical protein -
KAF59_RS15355 (KAF59_15355) 333393..333860 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T199000 WP_000277238.1 NZ_CP072850:c329169-328900 [Vibrio cholerae MO10]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T199000 NZ_CP097083:c24143-23661 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACAAAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT199000 WP_001258569.1 NZ_CP072850:c329440-329162 [Vibrio cholerae MO10]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT199000 NZ_CP097083:c24412-24134 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References