Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 497743..498527 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag IT766_RS16375 Protein ID WP_001114075.1
Coordinates 497743..498012 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag IT766_RS16380 Protein ID WP_000921691.1
Coordinates 498006..498527 (+) Length 174 a.a.

Genomic Context

IT766_RS16335IT766_RS16340IT766_RS16345IT766_RS16350IT766_RS16355IT766_RS16360IT766_RS16365IT766_RS16370IT766_RS16375IT766_RS16380IT766_RS16385IT766_RS16390IT766_RS16405IT766_RS16410IT766_RS16415IT766_RS16395IT766_RS16400
Location: 493109..494026 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 494183..494572 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 494708..494917 (210 bp)
Type: Others
Protein ID: Protein_519
Location: 495036..495473 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 495537..495755 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 495930..496802 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 496952..497551 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 497608..497712 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 497743..498012 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 498006..498527 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 498826..498951 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 499202..499597 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 500489..501004 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 501188..501601 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 502156..503333 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 499736..500014 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 500011..500295 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT766_RS16335493109..494026+918WP_000186333.1alpha/beta hydrolase-
IT766_RS16340494183..494572+390WP_001081302.1hypothetical protein-
IT766_RS16345494708..494917+210Protein_519GNAT family N-acetyltransferase-
IT766_RS16350495036..495473+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
IT766_RS16355495537..495755+219WP_071908318.1GNAT family N-acetyltransferase-
IT766_RS16360495930..496802+873WP_000254716.1DUF3800 domain-containing protein-
IT766_RS16365496952..497551+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
IT766_RS16370497608..497712+105WP_099607150.1acetyltransferase-
IT766_RS16375497743..498012+270WP_001114075.1DUF4160 domain-containing proteinToxin
IT766_RS16380498006..498527+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
IT766_RS16385498826..498951+126WP_001905700.1DUF645 family protein-
IT766_RS16390499202..499597+396WP_001000867.1hypothetical protein-
IT766_RS16395499736..500014-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
IT766_RS16400500011..500295-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
IT766_RS16405500489..501004+516WP_000343779.1GNAT family N-acetyltransferase-
IT766_RS16410501188..501601+414WP_000049420.1VOC family protein-
IT766_RS16415502156..503333+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-373204..502464129260
insideIntegron--378284..502088123804
flankIS/Tn--495036..495473437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T180881 WP_001114075.1 NZ_CP064351:497743-498012 [Vibrio cholerae C6706]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T180881 NZ_CP085767:c4663914-4663811 [Enterobacter hormaechei]
GGCAGGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT180881 WP_000921691.1 NZ_CP064351:498006-498527 [Vibrio cholerae C6706]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT180881 NZ_CP085767:4663806-4664007 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCCTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References